# Prompt Injection 2.0: Hybrid AI Threats

arXiv: https://arxiv.org/abs/2507.13169 · HTML: https://mlsanity.com/paper/2507.13169/

## Key facts

- Cited by 13 papers in the map (data through 14 Oct 2026).
- Placed in Prompt injection and agent security, one of 12 directions in LLM safety and security.
- Builds on 21 of its 29 references that are in the map.
- First posted on arXiv 17 Jul 2025.

## Placed in

- LLM safety and security / [Prompt injection and agent security](https://mlsanity.com/safety/prompt-injection-and-agent-security/)

## Builds on (most cited first, 21 of 21)

- [Prompt Injection attack against LLM-integrated Applications](https://mlsanity.com/paper/2306.05499/) (2023)
- [Defeating Prompt Injections by Design](https://mlsanity.com/paper/2503.18813/) (2025)
- [Defending Against Indirect Prompt Injection Attacks With Spotlighting](https://mlsanity.com/paper/2403.14720/) (2024)
- [Benchmarking and Defending Against Indirect Prompt Injection Attacks on Large Language Models](https://mlsanity.com/paper/2312.14197/) (2023)
- [Prompt Infection: LLM-to-LLM Prompt Injection within Multi-Agent Systems](https://mlsanity.com/paper/2410.07283/) (2024)
- [Abusing Images and Sounds for Indirect Instruction Injection in Multi-Modal LLMs](https://mlsanity.com/paper/2307.10490/) (2023)
- [Automatic and Universal Prompt Injection Attacks against Large Language Models](https://mlsanity.com/paper/2403.04957/) (2024)
- [LLM Agents can Autonomously Hack Websites](https://mlsanity.com/paper/2402.06664/) (2024)
- [Design Patterns for Securing LLM Agents against Prompt Injections](https://mlsanity.com/paper/2506.08837/) (2025)
- [Evaluating the Susceptibility of Pre-Trained Language Models via Handcrafted Adversarial Examples](https://mlsanity.com/paper/2209.02128/) (2022)
- [Ignore This Title and HackAPrompt: Exposing Systemic Vulnerabilities of LLMs through a Global Scale Prompt Hacking Competition](https://mlsanity.com/paper/2311.16119/) (2023)
- [Here Comes The AI Worm: Unleashing Zero-click Worms that Target GenAI-Powered Applications](https://mlsanity.com/paper/2403.02817/) (2024)
- [From Prompt Injections to SQL Injection Attacks: How Protected is Your LLM-Integrated Web Application?](https://mlsanity.com/paper/2308.01990/) (2023)
- [Manipulating Multimodal Agents via Cross-Modal Prompt Injection](https://mlsanity.com/paper/2504.14348/) (2025)
- [Human-Imperceptible Retrieval Poisoning Attacks in LLM-Powered Applications](https://mlsanity.com/paper/2404.17196/) (2024)
- [Backdoored Retrievers for Prompt Injection Attacks on Retrieval Augmented Generation of Large Language Models](https://mlsanity.com/paper/2410.14479/) (2024)
- [Learning to Poison Large Language Models for Downstream Manipulation](https://mlsanity.com/paper/2402.13459/) (2024)
- [The Hidden Dangers of Browsing AI Agents](https://mlsanity.com/paper/2505.13076/) (2025)
- [Invisible Prompts, Visible Threats: Malicious Font Injection in External Resources for Large Language Models](https://mlsanity.com/paper/2505.16957/) (2025)
- [XOXO: Stealthy Cross-Origin Context Poisoning Attacks against AI Coding Assistants](https://mlsanity.com/paper/2503.14281/) (2025)
- [AI Ethics by Design: Implementing Customizable Guardrails for Responsible AI Development](https://mlsanity.com/paper/2411.14442/) (2024)

## Built on by (most cited first, 13 of 13)

- [Agentic AI Security: Threats, Defenses, Evaluation, and Open Challenges](https://mlsanity.com/paper/2510.23883/) (2025)
- [A Survey of Agentic AI and Cybersecurity: Challenges, Opportunities and Use-case Prototypes](https://mlsanity.com/paper/2601.05293/) (2026)
- [A Framework for Formalizing LLM Agent Security](https://mlsanity.com/paper/2603.19469/) (2026)
- [MCP-ITP: An Automated Framework for Implicit Tool Poisoning in MCP](https://mlsanity.com/paper/2601.07395/) (2026)
- [Semantic Attacks on Tool-Augmented LLMs: Securing the Model Context Protocol Against Descriptor-Level Manipulation](https://mlsanity.com/paper/2512.06556/) (2025)
- [POT: Inducing Overthinking in LLMs via Black-Box Iterative Optimization](https://mlsanity.com/paper/2508.19277/) (2025)
- [SOK: A Taxonomy of Attack Vectors and Defense Strategies for Agentic Supply Chain Runtime](https://mlsanity.com/paper/2602.19555/) (2026)
- [StealthGraph: Exposing Domain-Specific Risks in LLMs through Knowledge-Graph-Guided Harmful Prompt Generation](https://mlsanity.com/paper/2601.04740/) (2026)
- [Neuro-Symbolic AI for Cybersecurity: State of the Art, Challenges, and Opportunities](https://mlsanity.com/paper/2509.06921/) (2025)
- [How do AI agents talk about science and research? An exploration of scientific discussions on Moltbook using BERTopic](https://mlsanity.com/paper/2603.11375/) (2026)
- [The Anatomy of a Prompt Injection: A Component Model for Structured Analysis](https://mlsanity.com/paper/2608.07808/) (2026)
- [From Prompt Injection to Web Exploitation: Revisiting Classic Vulnerabilities in LLM-Integrated Applications](https://mlsanity.com/paper/2608.10281/) (2026)
- [Beyond Single-Model Injection: A Threat Model and Defense Architecture for Prompt Injection in Multi-Agent Systems](https://mlsanity.com/paper/2609.22949/) (2026)

## Abstract (arXiv)

Prompt injection attacks, where malicious input is designed to manipulate AI systems into ignoring their original instructions and following unauthorized commands instead, were first discovered by Preamble, Inc. in May 2022 and responsibly disclosed to OpenAI. Over the last three years, these attacks have continued to pose a critical security threat to LLM-integrated systems. The emergence of agentic AI systems, where LLMs autonomously perform multistep tasks through tools and coordination with other agents, has fundamentally transformed the threat landscape. Modern prompt injection attacks can now combine with traditional cybersecurity exploits to create hybrid threats that systematically evade traditional security controls. This paper presents a comprehensive analysis of Prompt Injection 2.0, examining how prompt injections integrate with Cross-Site Scripting (XSS), Cross-Site Request Forgery (CSRF), and other web security vulnerabilities to bypass traditional security measures. We build upon Preamble's foundational research and mitigation technologies, evaluating them against contemporary threats, including AI worms, multi-agent infections, and hybrid cyber-AI attacks. Our analysis incorporates recent benchmarks that demonstrate how traditional web application firewalls, XSS filters, and CSRF tokens fail against AI-enhanced attacks. We also present architectural solutions that combine prompt isolation, runtime security, and privilege separation with novel threat detection capabilities.