# Unleashing Vision Foundation Models for Coronary Artery Segmentation: Parallel ViT-CNN Encoding and Variational Fusion

arXiv: https://arxiv.org/abs/2507.12938 · HTML: https://mlsanity.com/paper/2507.12938/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 28 references that are in the map.
- First posted on arXiv 17 Jul 2025.

## Builds on (most cited first, 12 of 12)

- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [nnFormer: Interleaved Transformer for Volumetric Segmentation](https://mlsanity.com/paper/2109.03201/) (2021)
- [SAM-Med3D: Towards General-purpose Segmentation Models for Volumetric Medical Images](https://mlsanity.com/paper/2310.15161/) (2023)
- [Real-Time Scene Text Detection with Differentiable Binarization and Adaptive Scale Fusion](https://mlsanity.com/paper/2202.10304/) (2022)
- [ImageCAS: A Large-Scale Dataset and Benchmark for Coronary Artery Segmentation based on Computed Tomography Angiography Images](https://mlsanity.com/paper/2211.01607/) (2022)
- [CS2-Net: Deep Learning Segmentation of Curvilinear Structures in Medical Imaging](https://mlsanity.com/paper/2010.07486/) (2020)
- [TBraTS: Trusted Brain Tumor Segmentation](https://mlsanity.com/paper/2206.09309/) (2022)
- [Deep 3D Vessel Segmentation based on Cross Transformer Network](https://mlsanity.com/paper/2208.10148/) (2022)

## Built on by (most cited first, 1 of 1)

- [Anatomy Guided Coronary Artery Segmentation from CCTA Using Spatial Frequency Joint Modeling](https://mlsanity.com/paper/2512.12539/) (2025)

## Abstract (arXiv)

Accurate coronary artery segmentation is critical for computeraided diagnosis of coronary artery disease (CAD), yet it remains challenging due to the small size, complex morphology, and low contrast with surrounding tissues. To address these challenges, we propose a novel segmentation framework that leverages the power of vision foundation models (VFMs) through a parallel encoding architecture. Specifically, a vision transformer (ViT) encoder within the VFM captures global structural features, enhanced by the activation of the final two ViT blocks and the integration of an attention-guided enhancement (AGE) module, while a convolutional neural network (CNN) encoder extracts local details. These complementary features are adaptively fused using a cross-branch variational fusion (CVF) module, which models latent distributions and applies variational attention to assign modality-specific weights. Additionally, we introduce an evidential-learning uncertainty refinement (EUR) module, which quantifies uncertainty using evidence theory and refines uncertain regions by incorporating multi-scale feature aggregation and attention mechanisms, further enhancing segmentation accuracy. Extensive evaluations on one in-house and two public datasets demonstrate that the proposed framework significantly outperforms state-of-the-art methods, achieving superior performance in accurate coronary artery segmentation and showcasing strong generalization across multiple datasets. The code is available at https://github.com/d1c2x3/CAseg.