# Identifying Signatures of Image Phenotypes to Track Treatment Response in Liver Disease

arXiv: https://arxiv.org/abs/2507.12012 · HTML: https://mlsanity.com/paper/2507.12012/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 31 references that are in the map.
- First posted on arXiv 16 Jul 2025.

## Builds on (most cited first, 11 of 11)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Unsupervised Deep Embedding for Clustering Analysis](https://mlsanity.com/paper/1511.06335/) (2015)
- [Towards K-means-friendly Spaces: Simultaneous Deep Learning and Clustering](https://mlsanity.com/paper/1610.04794/) (2016)
- [Variational Deep Embedding: An Unsupervised and Generative Approach to Clustering](https://mlsanity.com/paper/1611.05148/) (2016)
- [Joint Unsupervised Learning of Deep Representations and Image Clusters](https://mlsanity.com/paper/1604.03628/) (2016)
- [Learning Discrete Representations via Information Maximizing Self-Augmented Training](https://mlsanity.com/paper/1702.08720/) (2017)
- [Deep Clustering via Joint Convolutional Autoencoder Embedding and Relative Entropy Minimization](https://mlsanity.com/paper/1704.06327/) (2017)
- [Discriminatively Boosted Image Clustering with Fully Convolutional Auto-Encoders](https://mlsanity.com/paper/1703.07980/) (2017)
- [Unsupervised Segmentation of 3D Medical Images Based on Clustering and Deep Representation Learning](https://mlsanity.com/paper/1804.03830/) (2018)
- [Unsupervised Joint Mining of Deep Features and Image Labels for Large-scale Radiology Image Categorization and Scene Recognition](https://mlsanity.com/paper/1701.06599/) (2017)

## Abstract (arXiv)

Quantifiable image patterns associated with disease progression and treatment response are critical tools for guiding individual treatment, and for developing novel therapies. Here, we show that unsupervised machine learning can identify a pattern vocabulary of liver tissue in magnetic resonance images that quantifies treatment response in diffuse liver disease. Deep clustering networks simultaneously encode and cluster patches of medical images into a low-dimensional latent space to establish a tissue vocabulary. The resulting tissue types capture differential tissue change and its location in the liver associated with treatment response. We demonstrate the utility of the vocabulary on a randomized controlled trial cohort of non-alcoholic steatohepatitis patients. First, we use the vocabulary to compare longitudinal liver change in a placebo and a treatment cohort. Results show that the method identifies specific liver tissue change pathways associated with treatment, and enables a better separation between treatment groups than established non-imaging measures. Moreover, we show that the vocabulary can predict biopsy derived features from non-invasive imaging data. We validate the method on a separate replication cohort to demonstrate the applicability of the proposed method.