# BenchReAD: A systematic benchmark for retinal anomaly detection

arXiv: https://arxiv.org/abs/2507.10492 · HTML: https://mlsanity.com/paper/2507.10492/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 29 references that are in the map.
- First posted on arXiv 14 Jul 2025.

## Builds on (most cited first, 16 of 16)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Towards Total Recall in Industrial Anomaly Detection](https://mlsanity.com/paper/2106.08265/) (2021)
- [Memorizing Normality to Detect Anomaly: Memory-augmented Deep Autoencoder for Unsupervised Anomaly Detection](https://mlsanity.com/paper/1904.02639/) (2019)
- [CutPaste: Self-Supervised Learning for Anomaly Detection and Localization](https://mlsanity.com/paper/2104.04015/) (2021)
- [Anomaly Detection via Reverse Distillation from One-Class Embedding](https://mlsanity.com/paper/2201.10703/) (2022)
- [SimpleNet: A Simple Network for Image Anomaly Detection and Localization](https://mlsanity.com/paper/2303.15140/) (2023)
- [Catching Both Gray and Black Swans: Open-set Supervised Anomaly Detection](https://mlsanity.com/paper/2203.14506/) (2022)
- [BMAD: Benchmarks for Medical Anomaly Detection](https://mlsanity.com/paper/2306.11876/) (2023)
- [Attention Based Glaucoma Detection: A Large-scale Database and CNN Model](https://mlsanity.com/paper/1903.10831/) (2019)
- [IM-IAD: Industrial Image Anomaly Detection Benchmark in Manufacturing](https://mlsanity.com/paper/2301.13359/) (2023)
- [ReContrast: Domain-Specific Anomaly Detection via Contrastive Reconstruction](https://mlsanity.com/paper/2306.02602/) (2023)
- [SoftPatch: Unsupervised Anomaly Detection with Noisy Data](https://mlsanity.com/paper/2403.14233/) (2024)
- [OCTID: Optical Coherence Tomography Image Database](https://mlsanity.com/paper/1812.07056/) (2018)
- [OCTDL: Optical Coherence Tomography Dataset for Image-Based Deep Learning Methods](https://mlsanity.com/paper/2312.08255/) (2023)
- [MedIAnomaly: A comparative study of anomaly detection in medical images](https://mlsanity.com/paper/2404.04518/) (2024)
- [GAN Ensemble for Anomaly Detection](https://mlsanity.com/paper/2012.07988/) (2020)

## Built on by (most cited first, 1 of 1)

- [Evidential Reasoning Advances Interpretable Real-World Disease Screening](https://mlsanity.com/paper/2605.15171/) (2026)

## Abstract (arXiv)

Retinal anomaly detection plays a pivotal role in screening ocular and systemic diseases. Despite its significance, progress in the field has been hindered by the absence of a comprehensive and publicly available benchmark, which is essential for the fair evaluation and advancement of methodologies. Due to this limitation, previous anomaly detection work related to retinal images has been constrained by (1) a limited and overly simplistic set of anomaly types, (2) test sets that are nearly saturated, and (3) a lack of generalization evaluation, resulting in less convincing experimental setups. Furthermore, existing benchmarks in medical anomaly detection predominantly focus on one-class supervised approaches (training only with negative samples), overlooking the vast amounts of labeled abnormal data and unlabeled data that are commonly available in clinical practice. To bridge these gaps, we introduce a benchmark for retinal anomaly detection, which is comprehensive and systematic in terms of data and algorithm. Through categorizing and benchmarking previous methods, we find that a fully supervised approach leveraging disentangled representations of abnormalities (DRA) achieves the best performance but suffers from significant drops in performance when encountering certain unseen anomalies. Inspired by the memory bank mechanisms in one-class supervised learning, we propose NFM-DRA, which integrates DRA with a Normal Feature Memory to mitigate the performance degradation, establishing a new SOTA. The benchmark is publicly available at https://github.com/DopamineLcy/BenchReAD.