# Multimodal Fusion at Three Tiers: Physics-Driven Data Generation and Vision-Language Guidance for Brain Tumor Segmentation

arXiv: https://arxiv.org/abs/2507.09966 · HTML: https://mlsanity.com/paper/2507.09966/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 31 of its 58 references that are in the map.
- First posted on arXiv 14 Jul 2025.

## Builds on (most cited first, 30 of 31)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [CBAM: Convolutional Block Attention Module](https://mlsanity.com/paper/1807.06521/) (2018)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [3D MRI brain tumor segmentation using autoencoder regularization](https://mlsanity.com/paper/1810.11654/) (2018)
- [TransBTS: Multimodal Brain Tumor Segmentation Using Transformer](https://mlsanity.com/paper/2103.04430/) (2021)
- [Diffusion Models for Implicit Image Segmentation Ensembles](https://mlsanity.com/paper/2112.03145/) (2021)
- [Concurrent Spatial and Channel Squeeze & Excitation in Fully Convolutional Networks](https://mlsanity.com/paper/1803.02579/) (2018)
- [Reducing the Hausdorff Distance in Medical Image Segmentation with Convolutional Neural Networks](https://mlsanity.com/paper/1904.10030/) (2019)
- [nnU-Net for Brain Tumor Segmentation](https://mlsanity.com/paper/2011.00848/) (2020)
- [Large-Vocabulary Segmentation for Medical Images with Text Prompts](https://mlsanity.com/paper/2312.17183/) (2023)
- [Diff-UNet: A Diffusion Embedded Network for Volumetric Segmentation](https://mlsanity.com/paper/2303.10326/) (2023)
- [Optimized U-Net for Brain Tumor Segmentation](https://mlsanity.com/paper/2110.03352/) (2021)
- [MedCLIP-SAM: Bridging Text and Image Towards Universal Medical Image Segmentation](https://mlsanity.com/paper/2403.20253/) (2024)
- [CKD-TransBTS: Clinical Knowledge-Driven Hybrid Transformer with Modality-Correlated Cross-Attention for Brain Tumor Segmentation](https://mlsanity.com/paper/2207.07370/) (2022)
- [Advanced Tumor Segmentation in Medical Imaging: An Ensemble Approach for BraTS 2023 Adult Glioma and Pediatric Tumor Tasks](https://mlsanity.com/paper/2403.09262/) (2024)
- [SegTransVAE: Hybrid CNN -- Transformer with Regularization for medical image segmentation](https://mlsanity.com/paper/2201.08582/) (2022)
- [Improved Multi-Task Brain Tumour Segmentation with Synthetic Data Augmentation](https://mlsanity.com/paper/2411.04632/) (2024)
- [FDiff-Fusion:Denoising diffusion fusion network based on fuzzy learning for 3D medical image segmentation](https://mlsanity.com/paper/2408.02075/) (2024)
- [CWT-Net: Super-resolution of Histopathology Images Using a Cross-scale Wavelet-based Transformer](https://mlsanity.com/paper/2409.07092/) (2024)

## Built on by (most cited first, 1 of 1)

- [Unified Multimodal Coherent Field: Synchronous Semantic-Spatial-Vision Fusion for Brain Tumor Segmentation](https://mlsanity.com/paper/2509.17520/) (2025)

## Abstract (arXiv)

Accurate brain tumor segmentation is crucial for neuro-oncology diagnosis and treatment planning. Deep learning methods have made significant progress, but automatic segmentation still faces challenges, including tumor morphological heterogeneity and complex three-dimensional spatial relationships. This paper proposes a three-tier fusion architecture that achieves precise brain tumor segmentation. The method processes information progressively at the pixel, feature, and semantic levels. At the pixel level, physical modeling extends magnetic resonance imaging (MRI) to multimodal data, including simulated ultrasound and synthetic computed tomography (CT). At the feature level, the method performs Transformer-based cross-modal feature fusion through multi-teacher collaborative distillation, integrating three expert teachers (MRI, US, CT). At the semantic level, clinical textual knowledge generated by GPT-4V is transformed into spatial guidance signals using CLIP contrastive learning and Feature-wise Linear Modulation (FiLM). These three tiers together form a complete processing chain from data augmentation to feature extraction to semantic guidance. We validated the method on the Brain Tumor Segmentation (BraTS) 2020, 2021, and 2023 datasets. The model achieves average Dice coefficients of 0.8665, 0.9014, and 0.8912 on the three datasets, respectively, and reduces the 95% Hausdorff Distance (HD95) by an average of 6.57 millimeters compared with the baseline. This method provides a new paradigm for precise tumor segmentation and boundary localization.