# 4D-MISR: A unified model for low-dose super-resolution imaging via feature fusion

arXiv: https://arxiv.org/abs/2507.09953 · HTML: https://mlsanity.com/paper/2507.09953/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 2 of its 8 references that are in the map.
- First posted on arXiv 14 Jul 2025.

## Builds on (most cited first, 2 of 2)

- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [Real-Time Single Image and Video Super-Resolution Using an Efficient Sub-Pixel Convolutional Neural Network](https://mlsanity.com/paper/1609.05158/) (2016)

## Abstract (arXiv)

While electron microscopy offers crucial atomic-resolution insights into structure-property relationships, radiation damage severely limits its use on beam-sensitive materials like proteins and 2D materials. To overcome this challenge, we push beyond the electron dose limits of conventional electron microscopy by adapting principles from multi-image super-resolution (MISR) that have been widely used in remote sensing. Our method fuses multiple low-resolution, sub-pixel-shifted views and enhances the reconstruction with a convolutional neural network (CNN) that integrates features from synthetic, multi-angle observations. We developed a dual-path, attention-guided network for 4D-STEM that achieves atomic-scale super-resolution from ultra-low-dose data. This provides robust atomic-scale visualization across amorphous, semi-crystalline, and crystalline beam-sensitive specimens. Systematic evaluations on representative materials demonstrate comparable spatial resolution to conventional ptychography under ultra-low-dose conditions. Our work expands the capabilities of 4D-STEM, offering a new and generalizable method for the structural analysis of radiation-vulnerable materials.