# Continual Multiple Instance Learning with Enhanced Localization for Histopathological Whole Slide Image Analysis

arXiv: https://arxiv.org/abs/2507.02395 · HTML: https://mlsanity.com/paper/2507.02395/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 54 of its 80 references that are in the map.
- First posted on arXiv 3 Jul 2025.

## Builds on (most cited first, 30 of 54)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Learning without Forgetting](https://mlsanity.com/paper/1606.09282/) (2016)
- [Gradient Episodic Memory for Continual Learning](https://mlsanity.com/paper/1706.08840/) (2017)
- [Visual Prompt Tuning](https://mlsanity.com/paper/2203.12119/) (2022)
- [Memory Aware Synapses: Learning what (not) to forget](https://mlsanity.com/paper/1711.09601/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Experience Replay for Continual Learning](https://mlsanity.com/paper/1811.11682/) (2018)
- [Efficient Lifelong Learning with A-GEM](https://mlsanity.com/paper/1812.00420/) (2018)
- [Learning to Prompt for Continual Learning](https://mlsanity.com/paper/2112.08654/) (2021)
- [Dark Experience for General Continual Learning: a Strong, Simple Baseline](https://mlsanity.com/paper/2004.07211/) (2020)
- [PackNet: Adding Multiple Tasks to a Single Network by Iterative Pruning](https://mlsanity.com/paper/1711.05769/) (2017)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [Riemannian Walk for Incremental Learning: Understanding Forgetting and Intransigence](https://mlsanity.com/paper/1801.10112/) (2018)
- [Overcoming catastrophic forgetting with hard attention to the task](https://mlsanity.com/paper/1801.01423/) (2018)
- [DualPrompt: Complementary Prompting for Rehearsal-free Continual Learning](https://mlsanity.com/paper/2204.04799/) (2022)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [Nystr"omformer: A Nystr"om-Based Algorithm for Approximating Self-Attention](https://mlsanity.com/paper/2102.03902/) (2021)
- [CODA-Prompt: COntinual Decomposed Attention-based Prompting for Rehearsal-Free Continual Learning](https://mlsanity.com/paper/2211.13218/) (2022)
- [Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learning](https://mlsanity.com/paper/2206.02647/) (2022)
- [Orthogonal Subspace Learning for Language Model Continual Learning](https://mlsanity.com/paper/2310.14152/) (2023)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [New Insights on Reducing Abrupt Representation Change in Online Continual Learning](https://mlsanity.com/paper/2104.05025/) (2021)
- [InfLoRA: Interference-Free Low-Rank Adaptation for Continual Learning](https://mlsanity.com/paper/2404.00228/) (2024)
- [Using Hindsight to Anchor Past Knowledge in Continual Learning](https://mlsanity.com/paper/2002.08165/) (2020)
- [Hierarchical Decomposition of Prompt-Based Continual Learning: Rethinking Obscured Sub-optimality](https://mlsanity.com/paper/2310.07234/) (2023)
- [Agent Attention: On the Integration of Softmax and Linear Attention](https://mlsanity.com/paper/2312.08874/) (2023)
- [A graph-transformer for whole slide image classification](https://mlsanity.com/paper/2205.09671/) (2022)
- [AFEC: Active Forgetting of Negative Transfer in Continual Learning](https://mlsanity.com/paper/2110.12187/) (2021)

## Built on by (most cited first, 2 of 2)

- [Forging a Dynamic Memory: Retrieval-Guided Continual Learning for Generalist Medical Foundation Models](https://mlsanity.com/paper/2512.13072/) (2025)
- [MergeSurv: Merging-Based Continual Learning for Survival Analysis on Whole-Slide Images](https://mlsanity.com/paper/2607.04747/) (2026)

## Abstract (arXiv)

Multiple instance learning (MIL) significantly reduced annotation costs via bag-level weak labels for large-scale images, such as histopathological whole slide images (WSIs). However, its adaptability to continual tasks with minimal forgetting has been rarely explored, especially on instance classification for localization. Weakly incremental learning for semantic segmentation has been studied for continual localization, but it focused on natural images, leveraging global relationships among hundreds of small patches (e.g., 16 × 16) using pre-trained models. This approach seems infeasible for MIL localization due to enormous amounts (~ 105) of large patches (e.g., 256 × 256) and no available global relationships such as cancer cells. To address these challenges, we propose Continual Multiple Instance Learning with Enhanced Localization (CoMEL), an MIL framework for both localization and adaptability with minimal forgetting. CoMEL consists of (1) Grouped Double Attention Transformer (GDAT) for efficient instance encoding, (2) Bag Prototypes-based Pseudo-Labeling (BPPL) for reliable instance pseudo-labeling, and (3) Orthogonal Weighted Low-Rank Adaptation (OWLoRA) to mitigate forgetting in both bag and instance classification. Extensive experiments on three public WSI datasets demonstrate superior performance of CoMEL, outperforming the prior arts by up to 11.00% in bag-level accuracy and up to 23.4% in localization accuracy under the continual MIL setup.