# HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3

arXiv: https://arxiv.org/abs/2507.02345 · HTML: https://mlsanity.com/paper/2507.02345/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 21 references that are in the map.
- First posted on arXiv 3 Jul 2025.

## Builds on (most cited first, 3 of 3)

- [Technical Report of HelixFold3 for Biomolecular Structure Prediction](https://mlsanity.com/paper/2408.16975/) (2024)
- [HelixFold-Multimer: Elevating Protein Complex Structure Prediction to New Heights](https://mlsanity.com/paper/2404.10260/) (2024)
- [Precise Antigen-Antibody Structure Predictions Enhance Antibody Development with HelixFold-Multimer](https://mlsanity.com/paper/2412.09826/) (2024)

## Abstract (arXiv)

Antibody engineering is essential for developing therapeutics and advancing biomedical research. Traditional discovery methods often rely on time-consuming and resource-intensive experimental screening. To enhance and streamline this process, we introduce a production-grade, high-throughput platform built on HelixFold3, HelixDesign-Antibody, which utilizes the high-accuracy structure prediction model, HelixFold3. The platform facilitates the large-scale generation of antibody candidate sequences and evaluates their interaction with antigens. Integrated high-performance computing (HPC) support enables high-throughput screening, addressing challenges such as fragmented toolchains and high computational demands. Validation on multiple antigens showcases the platform's ability to generate diverse and high-quality antibodies, confirming a scaling law where exploring larger sequence spaces increases the likelihood of identifying optimal binders. This platform provides a seamless, accessible solution for large-scale antibody design and is available via the antibody design page of PaddleHelix platform.