# Tied Prototype Model for Few-Shot Medical Image Segmentation

arXiv: https://arxiv.org/abs/2506.22101 · HTML: https://mlsanity.com/paper/2506.22101/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 26 references that are in the map.
- First posted on arXiv 27 Jun 2025.

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Prototypical Networks for Few-shot Learning](https://mlsanity.com/paper/1703.05175/) (2017)
- [PANet: Few-Shot Image Semantic Segmentation with Prototype Alignment](https://mlsanity.com/paper/1908.06391/) (2019)
- [TADAM: Task dependent adaptive metric for improved few-shot learning](https://mlsanity.com/paper/1805.10123/) (2018)
- [CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentation](https://mlsanity.com/paper/2001.06535/) (2020)
- [NormFace: L2 Hypersphere Embedding for Face Verification](https://mlsanity.com/paper/1704.06369/) (2017)
- [Prototype Mixture Models for Few-shot Semantic Segmentation](https://mlsanity.com/paper/2008.03898/) (2020)
- [Part-aware Prototype Network for Few-shot Semantic Segmentation](https://mlsanity.com/paper/2007.06309/) (2020)
- [Few-Shot Segmentation Without Meta-Learning: A Good Transductive Inference Is All You Need?](https://mlsanity.com/paper/2012.06166/) (2020)
- [Self-Supervision with Superpixels: Training Few-shot Medical Image Segmentation without Annotation](https://mlsanity.com/paper/2007.09886/) (2020)
- [Anomaly Detection-Inspired Few-Shot Medical Image Segmentation Through Self-Supervision With Supervoxels](https://mlsanity.com/paper/2203.02048/) (2022)
- [Few-Shot Medical Image Segmentation via a Region-enhanced Prototypical Transformer](https://mlsanity.com/paper/2309.04825/) (2023)
- [Q-Net: Query-Informed Few-Shot Medical Image Segmentation](https://mlsanity.com/paper/2208.11451/) (2022)
- [Partition-A-Medical-Image: Extracting Multiple Representative Sub-regions for Few-shot Medical Image Segmentation](https://mlsanity.com/paper/2309.11172/) (2023)
- [Self-Supervised Few-Shot Learning for Ischemic Stroke Lesion Segmentation](https://mlsanity.com/paper/2303.01332/) (2023)

## Built on by (most cited first, 1 of 1)

- [Attention-Based Prototype Calibration for Multi-Rater Few-Shot Medical Image Segmentation](https://mlsanity.com/paper/2606.16325/) (2026)

## Abstract (arXiv)

Common prototype-based medical image few-shot segmentation (FSS) methods model foreground and background classes using class-specific prototypes. However, given the high variability of the background, a more promising direction is to focus solely on foreground modeling, treating the background as an anomaly -- an approach introduced by ADNet. Yet, ADNet faces three key limitations: dependence on a single prototype per class, a focus on binary classification, and fixed thresholds that fail to adapt to patient and organ variability. To address these shortcomings, we propose the Tied Prototype Model (TPM), a principled reformulation of ADNet with tied prototype locations for foreground and background distributions. Building on its probabilistic foundation, TPM naturally extends to multiple prototypes and multi-class segmentation while effectively separating non-typical background features. Notably, both extensions lead to improved segmentation accuracy. Finally, we leverage naturally occurring class priors to define an ideal target for adaptive thresholds, boosting segmentation performance. Taken together, TPM provides a fresh perspective on prototype-based FSS for medical image segmentation. The code can be found at https://github.com/hjk92g/TPM-FSS.