# HQCM-EBTC: A Hybrid Quantum-Classical Model for Explainable Brain Tumor Classification

arXiv: https://arxiv.org/abs/2506.21937 · HTML: https://mlsanity.com/paper/2506.21937/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 39 references that are in the map.
- First posted on arXiv 27 Jun 2025.

## Builds on (most cited first, 5 of 5)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Brain Tumor Diagnosis Using Quantum Convolutional Neural Networks](https://mlsanity.com/paper/2401.15804/) (2024)

## Abstract (arXiv)

We propose HQCM-EBTC, a hybrid quantum-classical model for automated brain tumor classification using MRI images. Trained on a dataset of 7,576 scans covering normal, meningioma, glioma, and pituitary classes, HQCM-EBTC integrates a 5-qubit, depth-2 quantum layer with 5 parallel circuits, optimized via AdamW and a composite loss blending cross-entropy and attention consistency. HQCM-EBTC achieves 96.48% accuracy, substantially outperforming the classical baseline (86.72%). It delivers higher precision and F1-scores, especially for glioma detection. t-SNE projections reveal enhanced feature separability in quantum space, and confusion matrices show lower misclassification. Attention map analysis (Jaccard Index) confirms more accurate and focused tumor localization at high-confidence thresholds. These results highlight the promise of quantum-enhanced models in medical imaging, advancing both diagnostic accuracy and interpretability for clinical brain tumor assessment.