# Style-Aligned Image Composition for Robust Detection of Abnormal Cells in Cytopathology

arXiv: https://arxiv.org/abs/2506.21001 · HTML: https://mlsanity.com/paper/2506.21001/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 20 references that are in the map.
- First posted on arXiv 26 Jun 2025.

## Builds on (most cited first, 13 of 13)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [An overview of gradient descent optimization algorithms](https://mlsanity.com/paper/1609.04747/) (2016)
- [GLIGEN: Open-Set Grounded Text-to-Image Generation](https://mlsanity.com/paper/2301.07093/) (2023)
- [Paint by Example: Exemplar-based Image Editing with Diffusion Models](https://mlsanity.com/paper/2211.13227/) (2022)
- [Comparison-Based Convolutional Neural Networks for Cervical Cell/Clumps Detection in the Limited Data Scenario](https://mlsanity.com/paper/1810.05952/) (2018)
- [Two-stage Cytopathological Image Synthesis for Augmenting Cervical Abnormality Screening](https://mlsanity.com/paper/2402.14707/) (2024)

## Abstract (arXiv)

Challenges such as the lack of high-quality annotations, long-tailed data distributions, and inconsistent staining styles pose significant obstacles to training neural networks to detect abnormal cells in cytopathology robustly. This paper proposes a style-aligned image composition (SAIC) method that composes high-fidelity and style-preserved pathological images to enhance the effectiveness and robustness of detection models. Without additional training, SAIC first selects an appropriate candidate from the abnormal cell bank based on attribute guidance. Then, it employs a high-frequency feature reconstruction to achieve a style-aligned and high-fidelity composition of abnormal cells and pathological backgrounds. Finally, it introduces a large vision-language model to filter high-quality synthesis images. Experimental results demonstrate that incorporating SAIC-synthesized images effectively enhances the performance and robustness of abnormal cell detection for tail categories and styles, thereby improving overall detection performance. The comprehensive quality evaluation further confirms the generalizability and practicality of SAIC in clinical application scenarios. Our code will be released at https://github.com/Joey-Qi/SAIC.