# Evaluating PDE discovery methods for multiscale modeling of biological signals

arXiv: https://arxiv.org/abs/2506.20694 · HTML: https://mlsanity.com/paper/2506.20694/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 37 references that are in the map.
- First posted on arXiv 25 Jun 2025.

## Builds on (most cited first, 12 of 12)

- [Automatic differentiation in machine learning: a survey](https://mlsanity.com/paper/1502.05767/) (2015)
- [PDE-Net: Learning PDEs from Data](https://mlsanity.com/paper/1710.09668/) (2017)
- [PDE-Net 2.0: Learning PDEs from Data with A Numeric-Symbolic Hybrid Deep Network](https://mlsanity.com/paper/1812.04426/) (2018)
- [Physics-informed learning of governing equations from scarce data](https://mlsanity.com/paper/2005.03448/) (2020)
- [Weak SINDy For Partial Differential Equations](https://mlsanity.com/paper/2007.02848/) (2020)
- [DeepMoD: Deep learning for Model Discovery in noisy data](https://mlsanity.com/paper/1904.09406/) (2019)
- [DLGA-PDE: Discovery of PDEs with incomplete candidate library via combination of deep learning and genetic algorithm](https://mlsanity.com/paper/2001.07305/) (2020)
- [Any equation is a forest: Symbolic genetic algorithm for discovering open-form partial differential equations (SGA-PDE)](https://mlsanity.com/paper/2106.11927/) (2021)
- [Robust discovery of partial differential equations in complex situations](https://mlsanity.com/paper/2106.00008/) (2021)
- [Bayesian Spline Learning for Equation Discovery of Nonlinear Dynamics with Quantified Uncertainty](https://mlsanity.com/paper/2210.08095/) (2022)
- [Physics-constrained robust learning of open-form partial differential equations from limited and noisy data](https://mlsanity.com/paper/2309.07672/) (2023)
- [D-CIPHER: Discovery of Closed-form Partial Differential Equations](https://mlsanity.com/paper/2206.10586/) (2022)

## Built on by (most cited first, 2 of 2)

- [Data-driven discovery of governing differential equations across physical systems](https://mlsanity.com/paper/2606.09638/) (2026)
- [On the post-hoc Evaluation of PDE Discovery: A Multifaceted Challenge of Scientific Advancement](https://mlsanity.com/paper/2607.23753/) (2026)

## Abstract (arXiv)

Biological systems are non-linear, include unobserved variables and the physical principles that govern their dynamics are partly unknown. This makes the characterization of their behavior very challenging. Notably, their activity occurs on multiple interdependent spatial and temporal scales that require linking mechanisms across scales. To address the challenge of bridging gaps between scales, we leverage partial differential equations (PDE) discovery. PDE discovery suggests meso-scale dynamics characteristics from micro-scale data. In this article, we present our framework combining particle-based simulations and PDE discovery and conduct preliminary experiments to assess equation discovery in controlled settings. We evaluate five state-of-the-art PDE discovery methods on particle-based simulations of calcium diffusion in astrocytes. The performances of the methods are evaluated on both the form of the discovered equation and the forecasted temporal variations of calcium concentration. Our results show that several methods accurately recover the diffusion term, highlighting the potential of PDE discovery for capturing macroscopic dynamics in biological systems from microscopic data.