# MAM: Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis via Role-Specialized Collaboration

arXiv: https://arxiv.org/abs/2506.19835 · HTML: https://mlsanity.com/paper/2506.19835/

## Key facts

- Cited by 40 papers in the map (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 24 of its 46 references that are in the map.
- First posted on arXiv 24 Jun 2025.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)
- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 24 of 24)

- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolution](https://mlsanity.com/paper/2409.12191/) (2024)
- [Don't Stop Pretraining: Adapt Language Models to Domains and Tasks](https://mlsanity.com/paper/2004.10964/) (2020)
- [Video-LLaMA: An Instruction-tuned Audio-Visual Language Model for Video Understanding](https://mlsanity.com/paper/2306.02858/) (2023)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [ExpeL: LLM Agents Are Experiential Learners](https://mlsanity.com/paper/2308.10144/) (2023)
- [VideoLLaMA 2: Advancing Spatial-Temporal Modeling and Audio Understanding in Video-LLMs](https://mlsanity.com/paper/2406.07476/) (2024)
- [Qwen-Audio: Advancing Universal Audio Understanding via Unified Large-Scale Audio-Language Models](https://mlsanity.com/paper/2311.07919/) (2023)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [Multi-Agent Collaboration: Harnessing the Power of Intelligent LLM Agents](https://mlsanity.com/paper/2306.03314/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [HuatuoGPT, towards Taming Language Model to Be a Doctor](https://mlsanity.com/paper/2305.15075/) (2023)
- [HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scale](https://mlsanity.com/paper/2406.19280/) (2024)
- [MathCoder: Seamless Code Integration in LLMs for Enhanced Mathematical Reasoning](https://mlsanity.com/paper/2310.03731/) (2023)
- [MAGIS: LLM-Based Multi-Agent Framework for GitHub Issue Resolution](https://mlsanity.com/paper/2403.17927/) (2024)
- [DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultation](https://mlsanity.com/paper/2308.14346/) (2023)
- [MathChat: Converse to Tackle Challenging Math Problems with LLM Agents](https://mlsanity.com/paper/2306.01337/) (2023)
- [Qilin-Med-VL: Towards Chinese Large Vision-Language Model for General Healthcare](https://mlsanity.com/paper/2310.17956/) (2023)
- [DeepLesion: Automated Deep Mining, Categorization and Detection of Significant Radiology Image Findings using Large-Scale Clinical Lesion Annotations](https://mlsanity.com/paper/1710.01766/) (2017)
- [Sound-Dr: Reliable Sound Dataset and Baseline Artificial Intelligence System for Respiratory Illnesses](https://mlsanity.com/paper/2201.04581/) (2022)

## Built on by (most cited first, 30 of 40)

- [CXRAgent: Director-Orchestrated Multi-Stage Reasoning for Chest X-Ray Interpretation](https://mlsanity.com/paper/2510.21324/) (2025)
- [TheraMind: A Strategic and Adaptive Agent for Longitudinal Psychological Counseling](https://mlsanity.com/paper/2510.25758/) (2025)
- [ClinTutor-R1: Advancing Scalable and Robust One-to-Many Alignment in Clinical Socratic Education](https://mlsanity.com/paper/2512.05671/) (2025)
- [Graph of States: Solving Abductive Tasks with Large Language Models](https://mlsanity.com/paper/2603.21250/) (2026)
- [XrayClaw: Cooperative-Competitive Multi-Agent Alignment for Trustworthy Chest X-ray Diagnosis](https://mlsanity.com/paper/2604.02695/) (2026)
- [Coherent Multimodal Reasoning with Iterative Self-Evaluation for Vision-Language Models](https://mlsanity.com/paper/2508.02886/) (2025)
- [ContextualLVLM-Agent: A Holistic Framework for Multi-Turn Visually-Grounded Dialogue and Complex Instruction Following](https://mlsanity.com/paper/2508.15164/) (2025)
- [MAS-Shield: A Defense Framework for Secure and Efficient LLM MAS](https://mlsanity.com/paper/2511.22924/) (2025)
- [Demystifying Low-Rank Knowledge Distillation in Large Language Models: Convergence, Generalization, and Information-Theoretic Guarantees](https://mlsanity.com/paper/2603.22355/) (2026)
- [MV-CoRe: Multimodal Visual-Conceptual Reasoning for Complex Visual Question Answering](https://mlsanity.com/paper/2508.07023/) (2025)
- [Sim4Seg: Boosting Multimodal Multi-disease Medical Diagnosis Segmentation with Region-Aware Vision-Language Similarity Masks](https://mlsanity.com/paper/2511.06665/) (2025)
- [Do Mixed-Vendor Multi-Agent LLMs Improve Clinical Diagnosis?](https://mlsanity.com/paper/2603.04421/) (2026)
- [PVminerLLM: Structured Extraction of Patient Voice from Patient-Generated Text using Large Language Models](https://mlsanity.com/paper/2603.05776/) (2026)
- [MetaAgent-X : Breaking the Ceiling of Automatic Multi-Agent Systems via End-to-End Reinforcement Learning](https://mlsanity.com/paper/2605.14212/) (2026)
- [The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomy](https://mlsanity.com/paper/2607.11175/) (2026)
- [Large Language Models for Zero-Shot Multicultural Name Recognition](https://mlsanity.com/paper/2507.04149/) (2025)
- [CIMR: Contextualized Iterative Multimodal Reasoning for Robust Instruction Following in LVLMs](https://mlsanity.com/paper/2507.22074/) (2025)
- [CAP-LLM: Context-Augmented Personalized Large Language Models for News Headline Generation](https://mlsanity.com/paper/2508.03935/) (2025)
- [LumiGen: An LVLM-Enhanced Iterative Framework for Fine-Grained Text-to-Image Generation](https://mlsanity.com/paper/2508.04732/) (2025)
- [DeCoT: Decomposing Complex Instructions for Enhanced Text-to-Image Generation with Large Language Models](https://mlsanity.com/paper/2508.12396/) (2025)
- [M3PO: Multimodal-Model-Guided Preference Optimization for Visual Instruction Following](https://mlsanity.com/paper/2508.12458/) (2025)
- [XDR-LVLM: An Explainable Vision-Language Large Model for Diabetic Retinopathy Diagnosis](https://mlsanity.com/paper/2508.15168/) (2025)
- [Hierarchical Contextual Grounding LVLM: Enhancing Fine-Grained Visual-Language Understanding with Robust Grounding](https://mlsanity.com/paper/2508.16974/) (2025)
- [Context-Adaptive Synthesis and Compression for Enhanced Retrieval-Augmented Generation in Complex Domains](https://mlsanity.com/paper/2508.19357/) (2025)
- [Thinking Like a Clinician: A Cognitive AI Agent for Clinical Diagnosis via Panoramic Profiling and Adversarial Debate](https://mlsanity.com/paper/2604.23605/) (2026)
- [Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning](https://mlsanity.com/paper/2607.07761/) (2026)
- [Unlocking Compositional Control: Self-Supervision for LVLM-Based Image Generation](https://mlsanity.com/paper/2507.04151/) (2025)
- [LVLM-Composer's Explicit Planning for Image Generation](https://mlsanity.com/paper/2507.04152/) (2025)
- [ContextGuard-LVLM: Enhancing News Veracity through Fine-grained Cross-modal Contextual Consistency Verification](https://mlsanity.com/paper/2508.06623/) (2025)
- [VL-MedGuide: A Visual-Linguistic Large Model for Intelligent and Explainable Skin Disease Auxiliary Diagnosis](https://mlsanity.com/paper/2508.06624/) (2025)

## Abstract (arXiv)

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs, comprehensiveness, and flexibility. To address these challenges, we introduce the Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis (MAM). Inspired by our empirical findings highlighting the benefits of role assignment and diagnostic discernment in LLMs, MAM decomposes the medical diagnostic process into specialized roles: a General Practitioner, Specialist Team, Radiologist, Medical Assistant, and Director, each embodied by an LLM-based agent. This modular and collaborative framework enables efficient knowledge updates and leverages existing medical LLMs and knowledge bases. Extensive experimental evaluations conducted on a wide range of publicly accessible multimodal medical datasets, incorporating text, image, audio, and video modalities, demonstrate that MAM consistently surpasses the performance of modality-specific LLMs. Notably, MAM achieves significant performance improvements ranging from 18% to 365% compared to baseline models. Our code is released at https://github.com/yczhou001/MAM.