# RWESummary: A Framework and Test for Choosing Large Language Models to Summarize Real-World Evidence (RWE) Studies

arXiv: https://arxiv.org/abs/2506.18819 · HTML: https://mlsanity.com/paper/2506.18819/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 26 references that are in the map.
- First posted on arXiv 23 Jun 2025.

## Builds on (most cited first, 10 of 10)

- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [Constitutional AI: Harmlessness from AI Feedback](https://mlsanity.com/paper/2212.08073/) (2022)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [HealthBench: Evaluating Large Language Models Towards Improved Human Health](https://mlsanity.com/paper/2505.08775/) (2025)
- [Replacing Judges with Juries: Evaluating LLM Generations with a Panel of Diverse Models](https://mlsanity.com/paper/2404.18796/) (2024)
- [Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarization](https://mlsanity.com/paper/2309.07430/) (2023)
- [Embers of Autoregression: Understanding Large Language Models Through the Problem They are Trained to Solve](https://mlsanity.com/paper/2309.13638/) (2023)
- [On Learning to Summarize with Large Language Models as References](https://mlsanity.com/paper/2305.14239/) (2023)
- [MedHELM: Holistic Evaluation of Large Language Models for Medical Tasks](https://mlsanity.com/paper/2505.23802/) (2025)
- [Evaluating LLMs with Multiple Problems at once](https://mlsanity.com/paper/2406.10786/) (2024)

## Abstract (arXiv)

Large Language Models (LLMs) have been extensively evaluated for general summarization tasks as well as medical research assistance, but they have not been specifically evaluated for the task of summarizing real-world evidence (RWE) from structured output of RWE studies. We introduce RWESummary, a proposed addition to the MedHELM framework (Bedi, Cui, Fuentes, Unell et al., 2025) to enable benchmarking of LLMs for this task. RWESummary includes one scenario and three evaluations covering major types of errors observed in summarization of medical research studies and was developed using Atropos Health proprietary data. Additionally, we use RWESummary to compare the performance of different LLMs in our internal RWE summarization tool. At the time of publication, with 13 distinct RWE studies, we found the Gemini 2.5 models performed best overall (both Flash and Pro). We suggest RWESummary as a novel and useful foundation model benchmark for real-world evidence study summarization.