# A Deep Convolutional Neural Network-Based Novel Class Balancing for Imbalance Data Segmentation

arXiv: https://arxiv.org/abs/2506.18474 · HTML: https://mlsanity.com/paper/2506.18474/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 58 references that are in the map.
- First posted on arXiv 23 Jun 2025.

## Builds on (most cited first, 9 of 9)

- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs](https://mlsanity.com/paper/1606.00915/) (2016)
- [Semantic Image Segmentation with Deep Convolutional Nets and Fully Connected CRFs](https://mlsanity.com/paper/1412.7062/) (2014)
- [DUNet: A deformable network for retinal vessel segmentation](https://mlsanity.com/paper/1811.01206/) (2018)
- [Unified Focal loss: Generalising Dice and cross entropy-based losses to handle class imbalanced medical image segmentation](https://mlsanity.com/paper/2102.04525/) (2021)
- [Fully Convolutional Adaptation Networks for Semantic Segmentation](https://mlsanity.com/paper/1804.08286/) (2018)
- [SA-UNet: Spatial Attention U-Net for Retinal Vessel Segmentation](https://mlsanity.com/paper/2004.03696/) (2020)
- [Deep Retinal Image Understanding](https://mlsanity.com/paper/1609.01103/) (2016)
- [A Fully Convolutional Neural Network based Structured Prediction Approach Towards the Retinal Vessel Segmentation](https://mlsanity.com/paper/1611.02064/) (2016)

## Abstract (arXiv)

Retinal fundus images provide valuable insights into the human eye's interior structure and crucial features, such as blood vessels, optic disk, macula, and fovea. However, accurate segmentation of retinal blood vessels can be challenging due to imbalanced data distribution and varying vessel thickness. In this paper, we propose BLCB-CNN, a novel pipeline based on deep learning and bi-level class balancing scheme to achieve vessel segmentation in retinal fundus images. The BLCB-CNN scheme uses a Convolutional Neural Network (CNN) architecture and an empirical approach to balance the distribution of pixels across vessel and non-vessel classes and within thin and thick vessels. Level-I is used for vessel/non-vessel balancing and Level-II is used for thick/thin vessel balancing. Additionally, pre-processing of the input retinal fundus image is performed by Global Contrast Normalization (GCN), Contrast Limited Adaptive Histogram Equalization (CLAHE), and gamma corrections to increase intensity uniformity as well as to enhance the contrast between vessels and background pixels. The resulting balanced dataset is used for classification-based segmentation of the retinal vascular tree. We evaluate the proposed scheme on standard retinal fundus images and achieve superior performance measures, including an area under the ROC curve of 98.23%, Accuracy of 96.22%, Sensitivity of 81.57%, and Specificity of 97.65%. We also demonstrate the method's efficacy through external cross-validation on STARE images, confirming its generalization ability.