# Latent Space Analysis for Interpretable Uncertainty in Melanoma Classification

arXiv: https://arxiv.org/abs/2506.18414 · HTML: https://mlsanity.com/paper/2506.18414/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 4 of its 10 references that are in the map.
- First posted on arXiv 23 Jun 2025.

## Builds on (most cited first, 4 of 4)

- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [BCN20000: Dermoscopic Lesions in the Wild](https://mlsanity.com/paper/1908.02288/) (2019)
- [Anomaly Detection for Skin Disease Images Using Variational Autoencoder](https://mlsanity.com/paper/1807.01349/) (2018)
- [Exploring Variational Autoencoders for Medical Image Generation: A Comprehensive Study](https://mlsanity.com/paper/2411.07348/) (2024)

## Abstract (arXiv)

Melanoma is a highly aggressive skin cancer, making early and accurate diagnosis critical. While deep learning excels in skin lesion classification, standard ``black-box" models struggle to explain diagnostic uncertainty, limiting clinical trust. This work introduces a hybrid framework combining a class-aware adversarial Variational Autoencoder and an XGBoost classifier, transcending simple binary classification by leveraging a generative latent space for interpretable decision support. Guided by adversarial training, the model learns the visual characteristics of skin lesions and projects them into a continuous latent space, ensuring that similar images are grouped closely together. Trained on this latent space, the XGBoost classifier achieves a robust AUC of 0.868, competing closely with state-of-the-art models. For borderline cases, the framework enables clinicians to leverage the latent topology through Content-Based Image Retrieval. This provides a dual benefit: it allows the clinician to visually compare an ambiguous lesion against biopsy-confirmed precedents and acts as an early warning sign since a borderline classification can indicate that a lesion shares features of both nevi and melanomas, potentially requiring close monitoring. Our approach translates algorithmic hesitation into transparent, evidence-based visual support, bridging the gap between predictive performance and clinical trust.