# LVPNet: A Latent-variable-based Prediction-driven End-to-end Framework for Lossless Compression of Medical Images

arXiv: https://arxiv.org/abs/2506.17983 · HTML: https://mlsanity.com/paper/2506.17983/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 23 of its 43 references that are in the map.
- First posted on arXiv 22 Jun 2025.

## Builds on (most cited first, 23 of 23)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Variational Diffusion Models](https://mlsanity.com/paper/2107.00630/) (2021)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [Pixel Recurrent Neural Networks](https://mlsanity.com/paper/1601.06759/) (2016)
- [PixelCNN++: Improving the PixelCNN with Discretized Logistic Mixture Likelihood and Other Modifications](https://mlsanity.com/paper/1701.05517/) (2017)
- [Deep Generative Modelling: A Comparative Review of VAEs, GANs, Normalizing Flows, Energy-Based and Autoregressive Models](https://mlsanity.com/paper/2103.04922/) (2021)
- [Autoregressive Diffusion Models](https://mlsanity.com/paper/2110.02037/) (2021)
- [Don't Blame the ELBO! A Linear VAE Perspective on Posterior Collapse](https://mlsanity.com/paper/1911.02469/) (2019)
- [Practical Full Resolution Learned Lossless Image Compression](https://mlsanity.com/paper/1811.12817/) (2018)
- [Practical Lossless Compression with Latent Variables using Bits Back Coding](https://mlsanity.com/paper/1901.04866/) (2019)
- [Integer Discrete Flows and Lossless Compression](https://mlsanity.com/paper/1905.07376/) (2019)
- [Bit-Swap: Recursive Bits-Back Coding for Lossless Compression with Hierarchical Latent Variables](https://mlsanity.com/paper/1905.06845/) (2019)
- [HiLLoC: Lossless Image Compression with Hierarchical Latent Variable Models](https://mlsanity.com/paper/1912.09953/) (2019)
- [Compression with Flows via Local Bits-Back Coding](https://mlsanity.com/paper/1905.08500/) (2019)
- [iVPF: Numerical Invertible Volume Preserving Flow for Efficient Lossless Compression](https://mlsanity.com/paper/2103.16211/) (2021)
- [iFlow: Numerically Invertible Flows for Efficient Lossless Compression via a Uniform Coder](https://mlsanity.com/paper/2111.00965/) (2021)
- [Noise-Consistent Siamese-Diffusion for Medical Image Synthesis and Segmentation](https://mlsanity.com/paper/2505.06068/) (2025)
- [Deep Lossy Plus Residual Coding for Lossless and Near-lossless Image Compression](https://mlsanity.com/paper/2209.04847/) (2022)
- [Learn From Zoom: Decoupled Supervised Contrastive Learning For WCE Image Classification](https://mlsanity.com/paper/2401.05771/) (2024)
- [Split Hierarchical Variational Compression](https://mlsanity.com/paper/2204.02071/) (2022)
- [Advancing Brain Imaging Analysis Step-by-step via Progressive Self-paced Learning](https://mlsanity.com/paper/2407.16128/) (2024)
- [On the Interplay of Human-AI Alignment,Fairness, and Performance Trade-offs in Medical Imaging](https://mlsanity.com/paper/2505.10231/) (2025)

## Built on by (most cited first, 2 of 2)

- [CRISP-SAM2: SAM2 with Cross-Modal Interaction and Semantic Prompting for Multi-Organ Segmentation](https://mlsanity.com/paper/2506.23121/) (2025)
- [Hierarchical Characterization of Brain Dynamics via State Space-based Vector Quantization](https://mlsanity.com/paper/2506.22952/) (2025)

## Abstract (arXiv)

Autoregressive Initial Bits is a framework that integrates sub-image autoregression and latent variable modeling, demonstrating its advantages in lossless medical image compression. However, in existing methods, the image segmentation process leads to an even distribution of latent variable information across each sub-image, which in turn causes posterior collapse and inefficient utilization of latent variables. To deal with these issues, we propose a prediction-based end-to-end lossless medical image compression method named LVPNet, leveraging global latent variables to predict pixel values and encoding predicted probabilities for lossless compression. Specifically, we introduce the Global Multi-scale Sensing Module (GMSM), which extracts compact and informative latent representations from the entire image, effectively capturing spatial dependencies within the latent space. Furthermore, to mitigate the information loss introduced during quantization, we propose the Quantization Compensation Module (QCM), which learns the distribution of quantization errors and refines the quantized features to compensate for quantization loss. Extensive experiments on challenging benchmarks demonstrate that our method achieves superior compression efficiency compared to state-of-the-art lossless image compression approaches, while maintaining competitive inference speed. The code is at https://github.com/scy-Jackel/LVPNet.