# Foundation Artificial Intelligence Models for Health Recognition Using Face Photographs (FAHR-Face)

arXiv: https://arxiv.org/abs/2506.14909 · HTML: https://mlsanity.com/paper/2506.14909/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 75 references that are in the map.
- First posted on arXiv 17 Jun 2025.

## Builds on (most cited first, 19 of 19)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [VGGFace2: A dataset for recognising faces across pose and age](https://mlsanity.com/paper/1710.08092/) (2017)
- [Age Progression/Regression by Conditional Adversarial Autoencoder](https://mlsanity.com/paper/1702.08423/) (2017)
- [Masked Autoencoders As Spatiotemporal Learners](https://mlsanity.com/paper/2205.09113/) (2022)
- [MADE: Masked Autoencoder for Distribution Estimation](https://mlsanity.com/paper/1502.03509/) (2015)
- [WebFace260M: A Benchmark Unveiling the Power of Million-Scale Deep Face Recognition](https://mlsanity.com/paper/2103.04098/) (2021)
- [RetinaFace: Single-stage Dense Face Localisation in the Wild](https://mlsanity.com/paper/1905.00641/) (2019)
- [MiVOLO: Multi-input Transformer for Age and Gender Estimation](https://mlsanity.com/paper/2307.04616/) (2023)
- [How to Understand Masked Autoencoders](https://mlsanity.com/paper/2202.03670/) (2022)
- [A Call to Reflect on Evaluation Practices for Age Estimation: Comparative Analysis of the State-of-the-Art and a Unified Benchmark](https://mlsanity.com/paper/2307.04570/) (2023)
- [Investigating Bias in Deep Face Analysis: The KANFace Dataset and Empirical Study](https://mlsanity.com/paper/2005.07302/) (2020)
- [Quantifying Facial Age by Posterior of Age Comparisons](https://mlsanity.com/paper/1708.09687/) (2017)
- [Understanding bias in facial recognition technologies](https://mlsanity.com/paper/2010.07023/) (2020)

## Abstract (arXiv)

Background: Facial appearance offers a noninvasive window into health. We built FAHR-Face, a foundation model trained on >40 million facial images and fine-tuned it for two distinct tasks: biological age estimation (FAHR-FaceAge) and survival risk prediction (FAHR-FaceSurvival). Methods: FAHR-FaceAge underwent a two-stage, age-balanced fine-tuning on 749,935 public images; FAHR-FaceSurvival was fine-tuned on 34,389 photos of cancer patients. Model robustness (cosmetic surgery, makeup, pose, lighting) and independence (saliency mapping) was tested extensively. Both models were clinically tested in two independent cancer patient datasets with survival analyzed by multivariable Cox models and adjusted for clinical prognostic factors. Findings: For age estimation, FAHR-FaceAge had the lowest mean absolute error of 5.1 years on public datasets, outperforming benchmark models and maintaining accuracy across the full human lifespan. In cancer patients, FAHR-FaceAge outperformed a prior facial age estimation model in survival prognostication. FAHR-FaceSurvival demonstrated robust prediction of mortality, and the highest-risk quartile had more than triple the mortality of the lowest (adjusted hazard ratio 3.22; P<0.001). These findings were validated in the independent cohort and both models showed generalizability across age, sex, race and cancer subgroups. The two algorithms provided distinct, complementary prognostic information; saliency mapping revealed each model relied on distinct facial regions. The combination of FAHR-FaceAge and FAHR-FaceSurvival improved prognostic accuracy. Interpretation: A single foundation model can generate inexpensive, scalable facial biomarkers that capture both biological ageing and disease-related mortality risk. The foundation model enabled effective training using relatively small clinical datasets.