# NeuroPhysNet: A FitzHugh-Nagumo-Based Physics-Informed Neural Network Framework for Electroencephalograph (EEG) Analysis and Motor Imagery Classification

arXiv: https://arxiv.org/abs/2506.13222 · HTML: https://mlsanity.com/paper/2506.13222/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 33 references that are in the map.
- First posted on arXiv 16 Jun 2025.

## Builds on (most cited first, 12 of 12)

- [Human Motion Diffusion Model](https://mlsanity.com/paper/2209.14916/) (2022)
- [EEGNet: A Compact Convolutional Network for EEG-based Brain-Computer Interfaces](https://mlsanity.com/paper/1611.08024/) (2016)
- [Learning the solution operator of parametric partial differential equations with physics-informed DeepOnets](https://mlsanity.com/paper/2103.10974/) (2021)
- [A Riemannian Network for SPD Matrix Learning](https://mlsanity.com/paper/1608.04233/) (2016)
- [Quantifying total uncertainty in physics-informed neural networks for solving forward and inverse stochastic problems](https://mlsanity.com/paper/1809.08327/) (2018)
- [Physics-Informed Machine Learning: A Survey on Problems, Methods and Applications](https://mlsanity.com/paper/2211.08064/) (2022)
- [Long-time integration of parametric evolution equations with physics-informed DeepONets](https://mlsanity.com/paper/2106.05384/) (2021)
- [FBCNet: A Multi-view Convolutional Neural Network for Brain-Computer Interface](https://mlsanity.com/paper/2104.01233/) (2021)
- [Tensor-CSPNet: A Novel Geometric Deep Learning Framework for Motor Imagery Classification](https://mlsanity.com/paper/2202.02472/) (2022)
- [Graph Neural Networks on SPD Manifolds for Motor Imagery Classification: A Perspective from the Time-Frequency Analysis](https://mlsanity.com/paper/2211.02641/) (2022)
- [Deep learning with convolutional neural networks for decoding and visualization of EEG pathology](https://mlsanity.com/paper/1708.08012/) (2017)
- [A Novel Convolutional Neural Network Architecture with a Continuous Symmetry](https://mlsanity.com/paper/2308.01621/) (2023)

## Abstract (arXiv)

Electroencephalography (EEG) is extensively employed in medical diagnostics and brain-computer interface (BCI) applications due to its non-invasive nature and high temporal resolution. However, EEG analysis faces significant challenges, including noise, nonstationarity, and inter-subject variability, which hinder its clinical utility. Traditional neural networks often lack integration with biophysical knowledge, limiting their interpretability, robustness, and potential for medical translation. To address these limitations, this study introduces NeuroPhysNet, a novel Physics-Informed Neural Network (PINN) framework tailored for EEG signal analysis and motor imagery classification in medical contexts. NeuroPhysNet incorporates the FitzHugh-Nagumo model, embedding neurodynamical principles to constrain predictions and enhance model robustness. Evaluated on the BCIC-IV-2a dataset, the framework achieved superior accuracy and generalization compared to conventional methods, especially in data-limited and cross-subject scenarios, which are common in clinical settings. By effectively integrating biophysical insights with data-driven techniques, NeuroPhysNet not only advances BCI applications but also holds significant promise for enhancing the precision and reliability of clinical diagnostics, such as motor disorder assessments and neurorehabilitation planning.