# ConStyX: Content Style Augmentation for Generalizable Medical Image Segmentation

arXiv: https://arxiv.org/abs/2506.10675 · HTML: https://mlsanity.com/paper/2506.10675/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 22 of its 27 references that are in the map.
- First posted on arXiv 12 Jun 2025.

## Builds on (most cited first, 22 of 22)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Generalizing to Unseen Domains: A Survey on Domain Generalization](https://mlsanity.com/paper/2103.03097/) (2021)
- [Domain Generalization: A Survey](https://mlsanity.com/paper/2103.02503/) (2021)
- [Domain Generalization with MixStyle](https://mlsanity.com/paper/2104.02008/) (2021)
- [Domain Adaptation for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2102.09508/) (2021)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [RobustNet: Improving Domain Generalization in Urban-Scene Segmentation via Instance Selective Whitening](https://mlsanity.com/paper/2103.15597/) (2021)
- [Robust and Generalizable Visual Representation Learning via Random Convolutions](https://mlsanity.com/paper/2007.13003/) (2020)
- [Deep Semantic Segmentation of Natural and Medical Images: A Review](https://mlsanity.com/paper/1910.07655/) (2019)
- [Uncertainty Modeling for Out-of-Distribution Generalization](https://mlsanity.com/paper/2202.03958/) (2022)
- [Exact Feature Distribution Matching for Arbitrary Style Transfer and Domain Generalization](https://mlsanity.com/paper/2203.07740/) (2022)
- [Deep Feature Interpolation for Image Content Changes](https://mlsanity.com/paper/1611.05507/) (2016)
- [Semantic-Aware Domain Generalized Segmentation](https://mlsanity.com/paper/2204.00822/) (2022)
- [Regularizing Deep Networks with Semantic Data Augmentation](https://mlsanity.com/paper/2007.10538/) (2020)
- [DGInStyle: Domain-Generalizable Semantic Segmentation with Image Diffusion Models and Stylized Semantic Control](https://mlsanity.com/paper/2312.03048/) (2023)
- [Devil is in Channels: Contrastive Single Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2306.05254/) (2023)
- [MaxStyle: Adversarial Style Composition for Robust Medical Image Segmentation](https://mlsanity.com/paper/2206.01737/) (2022)
- [Treasure in Distribution: A Domain Randomization based Multi-Source Domain Generalization for 2D Medical Image Segmentation](https://mlsanity.com/paper/2305.19949/) (2023)
- [Domain Generalization with Correlated Style Uncertainty](https://mlsanity.com/paper/2212.09950/) (2022)
- [MoreStyle: Relax Low-frequency Constraint of Fourier-based Image Reconstruction in Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2403.11689/) (2024)

## Built on by (most cited first, 1 of 1)

- [PhaseAT: Fourier Phase Adversarial Training for Medical Image Domain Generalization](https://mlsanity.com/paper/2610.01807/) (2026)

## Abstract (arXiv)

Medical images are usually collected from multiple domains, leading to domain shifts that impair the performance of medical image segmentation models. Domain Generalization (DG) aims to address this issue by training a robust model with strong generalizability. Recently, numerous domain randomization-based DG methods have been proposed. However, these methods suffer from the following limitations: 1) constrained efficiency of domain randomization due to their exclusive dependence on image style perturbation, and 2) neglect of the adverse effects of over-augmented images on model training. To address these issues, we propose a novel domain randomization-based DG method, called content style augmentation (ConStyX), for generalizable medical image segmentation. Specifically, ConStyX 1) augments the content and style of training data, allowing the augmented training data to better cover a wider range of data domains, and 2) leverages well-augmented features while mitigating the negative effects of over-augmented features during model training. Extensive experiments across multiple domains demonstrate that our ConStyX achieves superior generalization performance. The code is available at https://github.com/jwxsp1/ConStyX.