# Foundation Models in Medical Imaging: A Review and Outlook

arXiv: https://arxiv.org/abs/2506.09095 · HTML: https://mlsanity.com/paper/2506.09095/

## Key facts

- Cited by 8 papers in the map (data through 14 Oct 2026).
- Builds on 144 of its 210 references that are in the map.
- First posted on arXiv 10 Jun 2025.

## Builds on (most cited first, 30 of 144)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Scaling Up Visual and Vision-Language Representation Learning With Noisy Text Supervision](https://mlsanity.com/paper/2102.05918/) (2021)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [Finetuned Language Models Are Zero-Shot Learners](https://mlsanity.com/paper/2109.01652/) (2021)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [BEiT: BERT Pre-Training of Image Transformers](https://mlsanity.com/paper/2106.08254/) (2021)
- [Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutions](https://mlsanity.com/paper/2102.12122/) (2021)
- [Visual Prompt Tuning](https://mlsanity.com/paper/2203.12119/) (2022)

## Built on by (most cited first, 8 of 8)

- [RAU: Reference-based Anatomical Understanding with Vision Language Models](https://mlsanity.com/paper/2509.22404/) (2025)
- [Diffusion-Driven Generation of Minimally Preprocessed Brain MRI](https://mlsanity.com/paper/2510.26834/) (2025)
- [Evaluating Fundus-Specific Foundation Models for Diabetic Macular Edema Detection](https://mlsanity.com/paper/2510.07277/) (2025)
- [Foundation Models for Medical Imaging: Status, Challenges, and Directions](https://mlsanity.com/paper/2602.15913/) (2026)
- [From Kellgren-Lawrence to Calcium Pyrophosphate Crystal Deposition: A Soft-Labelling Framework for Knee Osteoarthritis Assessmen](https://mlsanity.com/paper/2605.28176/) (2026)
- [Beyond Natural-Image Foundation Models: Benchmarking Satellite Pretraining for Ophthalmic Image Analysis](https://mlsanity.com/paper/2608.15195/) (2026)
- [Mammography Foundation Models for Opportunistic Prediction of Major Adverse Cardiovascular Events](https://mlsanity.com/paper/2609.19385/) (2026)
- [Image-Based Breast Implant Detection for Mammography Dataset Curation and Near-Real-Time Deployment: Comparing Foundation Models and Task-Specific Convolutional Models](https://mlsanity.com/paper/2610.03817/) (2026)

## Abstract (arXiv)

Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features that can later be adapted to specific clinical tasks with little additional supervision. In this review, we examine how FMs are being developed and applied in pathology, radiology, and ophthalmology, drawing on evidence from over 150 studies. We explain the core components of FM pipelines, including model architectures, self-supervised learning methods, and strategies for downstream adaptation. We also review how FMs are being used in each imaging domain and compare design choices across applications. Finally, we discuss key challenges and open questions to guide future research.