# MAMBO: High-Resolution Generative Approach for Mammography Images

arXiv: https://arxiv.org/abs/2506.08677 · HTML: https://mlsanity.com/paper/2506.08677/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 22 of its 49 references that are in the map.
- First posted on arXiv 10 Jun 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 22 of 22)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [Zero-Shot Image Restoration Using Denoising Diffusion Null-Space Model](https://mlsanity.com/paper/2212.00490/) (2022)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [Scaling up GANs for Text-to-Image Synthesis](https://mlsanity.com/paper/2303.05511/) (2023)
- [Deep Learning for Image Super-resolution: A Survey](https://mlsanity.com/paper/1902.06068/) (2019)
- [Diffusion Models for Medical Anomaly Detection](https://mlsanity.com/paper/2203.04306/) (2022)
- [End-to-end Training for Whole Image Breast Cancer Diagnosis using An All Convolutional Design](https://mlsanity.com/paper/1711.05775/) (2017)
- [VinDr-Mammo: A large-scale benchmark dataset for computer-aided diagnosis in full-field digital mammography](https://mlsanity.com/paper/2203.11205/) (2022)
- [Generative AI for Medical Imaging: extending the MONAI Framework](https://mlsanity.com/paper/2307.15208/) (2023)
- [Patched Denoising Diffusion Models For High-Resolution Image Synthesis](https://mlsanity.com/paper/2308.01316/) (2023)
- [Mammo-CLIP: A Vision Language Foundation Model to Enhance Data Efficiency and Robustness in Mammography](https://mlsanity.com/paper/2405.12255/) (2024)
- [Diffusion Models with Implicit Guidance for Medical Anomaly Detection](https://mlsanity.com/paper/2403.08464/) (2024)
- [Knowledge-based in silico models and dataset for the comparative evaluation of mammography AI for a range of breast characteristics, lesion conspicuities and doses](https://mlsanity.com/paper/2310.18494/) (2023)

## Abstract (arXiv)

Mammography is the gold standard for the detection and diagnosis of breast cancer. This procedure can be significantly enhanced with Artificial Intelligence (AI)-based software, which assists radiologists in identifying abnormalities. However, training AI systems requires large and diverse datasets, which are often difficult to obtain due to privacy and ethical constraints. To address this issue, the paper introduces MAMmography ensemBle mOdel (MAMBO), a novel patch-based diffusion approach designed to generate full-resolution mammograms. Diffusion models have shown breakthrough results in realistic image generation, yet few studies have focused on mammograms, and none have successfully generated high-resolution outputs required to capture fine-grained features of small lesions. To achieve this, MAMBO integrates separate diffusion models to capture both local and global (image-level) contexts. The contextual information is then fed into the final model, significantly aiding the noise removal process. This design enables MAMBO to generate highly realistic mammograms of up to 3840x3840 pixels. Importantly, this approach can be used to enhance the training of classification models and extended to anomaly segmentation. Experiments, both numerical and radiologist validation, assess MAMBO's capabilities in image generation, super-resolution, and anomaly segmentation, highlighting its potential to enhance mammography analysis for more accurate diagnoses and earlier lesion detection. The source code used in this study is publicly available at: https://github.com/iai-rs/mambo.