# Progressive Tempering Sampler with Diffusion

arXiv: https://arxiv.org/abs/2506.05231 · HTML: https://mlsanity.com/paper/2506.05231/

## Key facts

- Cited by 13 papers in the map (data through 14 Oct 2026).
- Placed in Diffusion foundations and sampling, one of 14 directions in Diffusion models.
- Builds on 39 of its 73 references that are in the map.
- First posted on arXiv 5 Jun 2025.

## Placed in

- Diffusion models / [Diffusion foundations and sampling](https://mlsanity.com/diffusion/diffusion-foundations-and-sampling/)

## Builds on (most cited first, 30 of 39)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [DreamFusion: Text-to-3D using 2D Diffusion](https://mlsanity.com/paper/2209.14988/) (2022)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [E(n) Equivariant Graph Neural Networks](https://mlsanity.com/paper/2102.09844/) (2021)
- [Compositional Visual Generation with Composable Diffusion Models](https://mlsanity.com/paper/2206.01714/) (2022)
- [FFJORD: Free-form Continuous Dynamics for Scalable Reversible Generative Models](https://mlsanity.com/paper/1810.01367/) (2018)
- [Guiding a Diffusion Model with a Bad Version of Itself](https://mlsanity.com/paper/2406.02507/) (2024)
- [Equivariant Flows: Exact Likelihood Generative Learning for Symmetric Densities](https://mlsanity.com/paper/2006.02425/) (2020)
- [Diff-Instruct: A Universal Approach for Transferring Knowledge From Pre-trained Diffusion Models](https://mlsanity.com/paper/2305.18455/) (2023)
- [Reduce, Reuse, Recycle: Compositional Generation with Energy-Based Diffusion Models and MCMC](https://mlsanity.com/paper/2302.11552/) (2023)
- [Path Integral Sampler: a stochastic control approach for sampling](https://mlsanity.com/paper/2111.15141/) (2021)
- [Stochastic Normalizing Flows](https://mlsanity.com/paper/2002.06707/) (2020)
- [Denoising Diffusion Samplers](https://mlsanity.com/paper/2302.13834/) (2023)
- [Equivariant flow matching](https://mlsanity.com/paper/2306.15030/) (2023)
- [Flow Annealed Importance Sampling Bootstrap](https://mlsanity.com/paper/2208.01893/) (2022)
- [Iterated Denoising Energy Matching for Sampling from Boltzmann Densities](https://mlsanity.com/paper/2402.06121/) (2024)
- [Feynman-Kac Correctors in Diffusion: Annealing, Guidance, and Product of Experts](https://mlsanity.com/paper/2503.02819/) (2025)
- [Annealed Flow Transport Monte Carlo](https://mlsanity.com/paper/2102.07501/) (2021)
- [Adjoint Sampling: Highly Scalable Diffusion Samplers via Adjoint Matching](https://mlsanity.com/paper/2504.11713/) (2025)
- [NETS: A Non-Equilibrium Transport Sampler](https://mlsanity.com/paper/2410.02711/) (2024)
- [Particle Denoising Diffusion Sampler](https://mlsanity.com/paper/2402.06320/) (2024)
- [Beyond ELBOs: A Large-Scale Evaluation of Variational Methods for Sampling](https://mlsanity.com/paper/2406.07423/) (2024)

## Built on by (most cited first, 13 of 13)

- [Progressive Inference-Time Annealing of Diffusion Models for Sampling from Boltzmann Densities](https://mlsanity.com/paper/2506.16471/) (2025)
- [Trust Region Constrained Measure Transport in Path Space for Stochastic Optimal Control and Inference](https://mlsanity.com/paper/2508.12511/) (2025)
- [MDNS: Masked Diffusion Neural Sampler via Stochastic Optimal Control](https://mlsanity.com/paper/2508.10684/) (2025)
- [CREPE: Controlling Diffusion with Replica Exchange](https://mlsanity.com/paper/2509.23265/) (2025)
- [Learning Boltzmann Generators via Constrained Mass Transport](https://mlsanity.com/paper/2510.18460/) (2025)
- [Diffusion Path Samplers via Sequential Monte Carlo](https://mlsanity.com/paper/2601.21951/) (2026)
- [Discrete Adjoint Schr"odinger Bridge Sampler](https://mlsanity.com/paper/2602.08243/) (2026)
- [Efficient Training of Boltzmann Generators Using Off-Policy Log-Dispersion Regularization](https://mlsanity.com/paper/2602.03729/) (2026)
- [Discrete diffusion samplers and bridges: Off-policy algorithms and applications in latent spaces](https://mlsanity.com/paper/2602.05961/) (2026)
- [Conditional Diffusion Sampling](https://mlsanity.com/paper/2605.04013/) (2026)
- [Scalable Inference-Time Annealing with Surrogate Likelihood Estimators](https://mlsanity.com/paper/2605.31498/) (2026)
- [Mode Collapse Is Cheap to Detect: A Ground-Truth-Free Pre-Flight Check for Neural Samplers](https://mlsanity.com/paper/2609.26272/) (2026)
- [Iterative Exact Discrete Guidance for Energy-Based Sampling](https://mlsanity.com/paper/2609.37043/) (2026)

## Abstract (arXiv)

Recent research has focused on designing neural samplers that amortize the process of sampling from unnormalized densities. However, despite significant advancements, they still fall short of the state-of-the-art MCMC approach, Parallel Tempering (PT), when it comes to the efficiency of target evaluations. On the other hand, unlike a well-trained neural sampler, PT yields only dependent samples and needs to be rerun -- at considerable computational cost -- whenever new samples are required. To address these weaknesses, we propose the Progressive Tempering Sampler with Diffusion (PTSD), which trains diffusion models sequentially across temperatures, leveraging the advantages of PT to improve the training of neural samplers. We also introduce a novel method to combine high-temperature diffusion models to generate approximate lower-temperature samples, which are minimally refined using MCMC and used to train the next diffusion model. PTSD enables efficient reuse of sample information across temperature levels while generating well-mixed, uncorrelated samples. Our method significantly improves target evaluation efficiency, outperforming diffusion-based neural samplers.