# Neural Network Reprogrammability: A Unified Theme on Model Reprogramming, Prompt Tuning, and Prompt Instruction

arXiv: https://arxiv.org/abs/2506.04650 · HTML: https://mlsanity.com/paper/2506.04650/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 130 of its 154 references that are in the map.
- First posted on arXiv 5 Jun 2025.

## Builds on (most cited first, 30 of 130)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Explaining and Harnessing Adversarial Examples](https://mlsanity.com/paper/1412.6572/) (2014)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Intriguing properties of neural networks](https://mlsanity.com/paper/1312.6199/) (2013)
- [Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks](https://mlsanity.com/paper/1703.03400/) (2017)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [Grounding DINO: Marrying DINO with Grounded Pre-Training for Open-Set Object Detection](https://mlsanity.com/paper/2303.05499/) (2023)
- [Universal and Transferable Adversarial Attacks on Aligned Language Models](https://mlsanity.com/paper/2307.15043/) (2023)
- [Towards Evaluating the Robustness of Neural Networks](https://mlsanity.com/paper/1608.04644/) (2016)
- [InstructBLIP: Towards General-purpose Vision-Language Models with Instruction Tuning](https://mlsanity.com/paper/2305.06500/) (2023)
- [Emergent Abilities of Large Language Models](https://mlsanity.com/paper/2206.07682/) (2022)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [The Lottery Ticket Hypothesis: Finding Sparse, Trainable Neural Networks](https://mlsanity.com/paper/1803.03635/) (2018)
- [Learn to Explain: Multimodal Reasoning via Thought Chains for Science Question Answering](https://mlsanity.com/paper/2209.09513/) (2022)

## Built on by (most cited first, 4 of 4)

- [Prompt-based Adaptation in Large-scale Vision Models: A Survey](https://mlsanity.com/paper/2510.13219/) (2025)
- [Let's Roll a BiFTA: Bi-refinement for Fine-grained Text-visual Alignment in Vision-Language Models](https://mlsanity.com/paper/2601.20419/) (2026)
- [LUMI: Tokenizer-Agnostic LLM-Based Lossless Image Compression](https://mlsanity.com/paper/2607.08221/) (2026)
- [WeatherBridge: Forecast-Aware Multi-Source Input Adaptation for Pretrained Weather Forecasting Models](https://mlsanity.com/paper/2610.14863/) (2026)

## Abstract (arXiv)

As large-scale pre-trained foundation models continue to expand in size and capability, efficiently adapting them to specific downstream tasks has become increasingly critical. Despite substantial progress, existing adaptation approaches have evolved largely in isolation, without a clear understanding of their interrelationships. This survey introduces neural network reprogrammability as a unifying framework that bridges mainstream model adaptation techniques--model reprogramming, prompt tuning, and prompt instruction--previously fragmented research areas yet converges on a shared principle: repurposing a pre-trained model by manipulating information at the interfaces while keeping the model parameters frozen. These methods exploit neural networks' sensitivity to manipulation on different interfaces, be it through perturbing inputs, inserting tokens into intermediate layers, or providing task-specific examples in context, to redirect model behaviors towards desired outcomes. We then present a taxonomy that categorizes such information manipulation-based adaptation approaches across four key dimensions: manipulation format (fixed or learnable), location (interfaces where manipulations occur), operator (how they are applied), and output alignment requirement (post-processing needed to align outputs with downstream tasks). Notably, this framework applies consistently across data modalities, independent of specific model architectures. Moreover, viewing established techniques like in-context learning and chain-of-thought prompting through this lens reveals both their theoretical connections and practical distinctions. We further analyze remaining technical challenges and ethical considerations, positioning neural network reprogrammability as a fundamental paradigm for efficient model adaptation. We lastly identify promising research directions emerging from this integrative viewpoint.