# Hybrid Ensemble of Segmentation-Assisted Classification and GBDT for Skin Cancer Detection with Engineered Metadata and Synthetic Lesions from ISIC 2024 Non-Dermoscopic 3D-TBP Images

arXiv: https://arxiv.org/abs/2506.03420 · HTML: https://mlsanity.com/paper/2506.03420/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 2 of its 22 references that are in the map.
- First posted on arXiv 3 Jun 2025.

## Builds on (most cited first, 2 of 2)

- [EVA-02: A Visual Representation for Neon Genesis](https://mlsanity.com/paper/2303.11331/) (2023)
- [EdgeNeXt: Efficiently Amalgamated CNN-Transformer Architecture for Mobile Vision Applications](https://mlsanity.com/paper/2206.10589/) (2022)

## Abstract (arXiv)

Skin cancer is among the most prevalent and life-threatening diseases worldwide, with early detection being critical to patient outcomes. This work presents a hybrid machine and deep learning-based approach for classifying malignant and benign skin lesions using the SLICE-3D dataset from ISIC 2024, which comprises 401,059 cropped lesion images extracted from 3D Total Body Photography (TBP), emulating non-dermoscopic, smartphone-like conditions. Our method combines vision transformers (EVA02) and our designed convolutional ViT hybrid (EdgeNeXtSAC) to extract robust features, employing a segmentation-assisted classification pipeline to enhance lesion localization. Predictions from these models are fused with a gradient-boosted decision tree (GBDT) ensemble enriched by engineered features and patient-specific relational metrics. To address class imbalance and improve generalization, we augment malignant cases with Stable Diffusion-generated synthetic lesions and apply a diagnosis-informed relabeling strategy to harmonize external datasets into a 3-class format. Using partial AUC (pAUC) above 80 percent true positive rate (TPR) as the evaluation metric, our approach achieves a pAUC of 0.1755 -- the highest among all configurations. These results underscore the potential of hybrid, interpretable AI systems for skin cancer triage in telemedicine and resource-constrained settings.