# Inference-Time Alignment of Diffusion Models via Evolutionary Algorithms

arXiv: https://arxiv.org/abs/2506.00299 · HTML: https://mlsanity.com/paper/2506.00299/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Diffusion foundations and sampling, one of 14 directions in Diffusion models.
- Builds on 40 of its 56 references that are in the map.
- First posted on arXiv 30 May 2025.

## Placed in

- Diffusion models / [Diffusion foundations and sampling](https://mlsanity.com/diffusion/diffusion-foundations-and-sampling/)

## Builds on (most cited first, 30 of 40)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [An Image is Worth One Word: Personalizing Text-to-Image Generation using Textual Inversion](https://mlsanity.com/paper/2208.01618/) (2022)
- [DiffWave: A Versatile Diffusion Model for Audio Synthesis](https://mlsanity.com/paper/2009.09761/) (2020)
- [ImageReward: Learning and Evaluating Human Preferences for Text-to-Image Generation](https://mlsanity.com/paper/2304.05977/) (2023)
- [Training Diffusion Models with Reinforcement Learning](https://mlsanity.com/paper/2305.13301/) (2023)
- [Pick-a-Pic: An Open Dataset of User Preferences for Text-to-Image Generation](https://mlsanity.com/paper/2305.01569/) (2023)
- [Human Preference Score v2: A Solid Benchmark for Evaluating Human Preferences of Text-to-Image Synthesis](https://mlsanity.com/paper/2306.09341/) (2023)
- [PixArt-α: Fast Training of Diffusion Transformer for Photorealistic Text-to-Image Synthesis](https://mlsanity.com/paper/2310.00426/) (2023)
- [Diffusion Model Alignment Using Direct Preference Optimization](https://mlsanity.com/paper/2311.12908/) (2023)
- [Evolution Strategies as a Scalable Alternative to Reinforcement Learning](https://mlsanity.com/paper/1703.03864/) (2017)
- [Directly Fine-Tuning Diffusion Models on Differentiable Rewards](https://mlsanity.com/paper/2309.17400/) (2023)
- [Aligning Text-to-Image Models using Human Feedback](https://mlsanity.com/paper/2302.12192/) (2023)
- [Training-Free Structured Diffusion Guidance for Compositional Text-to-Image Synthesis](https://mlsanity.com/paper/2212.05032/) (2022)
- [Aligning Text-to-Image Diffusion Models with Reward Backpropagation](https://mlsanity.com/paper/2310.03739/) (2023)
- [Human Preference Score: Better Aligning Text-to-Image Models with Human Preference](https://mlsanity.com/paper/2303.14420/) (2023)
- [Emu: Enhancing Image Generation Models Using Photogenic Needles in a Haystack](https://mlsanity.com/paper/2309.15807/) (2023)
- [Inference-Time Scaling for Diffusion Models beyond Scaling Denoising Steps](https://mlsanity.com/paper/2501.09732/) (2025)
- [A General Framework for Inference-time Scaling and Steering of Diffusion Models](https://mlsanity.com/paper/2501.06848/) (2025)
- [Optimizing Prompts for Text-to-Image Generation](https://mlsanity.com/paper/2212.09611/) (2022)
- [Deep Neuroevolution: Genetic Algorithms Are a Competitive Alternative for Training Deep Neural Networks for Reinforcement Learning](https://mlsanity.com/paper/1712.06567/) (2017)
- [Derivative-Free Guidance in Continuous and Discrete Diffusion Models with Soft Value-Based Decoding](https://mlsanity.com/paper/2408.08252/) (2024)
- [End-to-End Diffusion Latent Optimization Improves Classifier Guidance](https://mlsanity.com/paper/2303.13703/) (2023)
- [Evolving Deep Neural Networks](https://mlsanity.com/paper/1703.00548/) (2017)
- [Golden Noise for Diffusion Models: A Learning Framework](https://mlsanity.com/paper/2411.09502/) (2024)
- [Improving Text-to-Image Consistency via Automatic Prompt Optimization](https://mlsanity.com/paper/2403.17804/) (2024)

## Built on by (most cited first, 2 of 2)

- [Test-Time Scaling in Multimodal Foundation Models: A Comprehensive Survey of Generation and Reasoning](https://mlsanity.com/paper/2606.08231/) (2026)
- [DiffGA: Steering Frozen Diffusion Models for Materials Design via Evolutionary Search](https://mlsanity.com/paper/2610.14999/) (2026)

## Abstract (arXiv)

Diffusion models are state-of-the-art generative models, yet their samples often fail to satisfy application objectives such as safety constraints or domain-specific validity. Existing techniques for alignment require gradients, internal model access, or large computational budgets resulting in high compute demands, or lack of support for certain objectives. In response, we introduce an inference-time alignment framework based on evolutionary algorithms. We treat diffusion models as black boxes and search their latent space to maximize alignment objectives. Given equal or less running time, our method achieves 3-35% higher ImageReward scores than gradient-free and gradient-based methods. On the Open Image Preferences dataset, our method achieves competitive results across four popular alignment objectives. In terms of computational efficiency, we require 55% to 76% less GPU memory and are 72% to 80% faster than gradient-based methods.