# MedPAIR: Measuring Physicians and AI Relevance Alignment in Medical Question Answering

arXiv: https://arxiv.org/abs/2505.24040 · HTML: https://mlsanity.com/paper/2505.24040/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 40 of its 71 references that are in the map.
- First posted on arXiv 29 May 2025.

## Builds on (most cited first, 30 of 40)

- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Learn to Explain: Multimodal Reasoning via Thought Chains for Science Question Answering](https://mlsanity.com/paper/2209.09513/) (2022)
- [A Survey on LLM-as-a-Judge](https://mlsanity.com/paper/2411.15594/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Can Large Language Models Be an Alternative to Human Evaluations?](https://mlsanity.com/paper/2305.01937/) (2023)
- [LLM Evaluators Recognize and Favor Their Own Generations](https://mlsanity.com/paper/2404.13076/) (2024)
- [Enabling Large Language Models to Generate Text with Citations](https://mlsanity.com/paper/2305.14627/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [ERASER: A Benchmark to Evaluate Rationalized NLP Models](https://mlsanity.com/paper/1911.03429/) (2019)
- [MoverScore: Text Generation Evaluating with Contextualized Embeddings and Earth Mover Distance](https://mlsanity.com/paper/1909.02622/) (2019)
- [Ragas: Automated Evaluation of Retrieval Augmented Generation](https://mlsanity.com/paper/2309.15217/) (2023)
- [Reasoning Models Don't Always Say What They Think](https://mlsanity.com/paper/2505.05410/) (2025)
- [Does the Whole Exceed its Parts? The Effect of AI Explanations on Complementary Team Performance](https://mlsanity.com/paper/2006.14779/) (2020)
- [Judging the Judges: A Systematic Study of Position Bias in LLM-as-a-Judge](https://mlsanity.com/paper/2406.07791/) (2024)
- [MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding](https://mlsanity.com/paper/2501.18362/) (2025)
- [MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoning](https://mlsanity.com/paper/2406.00922/) (2024)
- [Evaluating Correctness and Faithfulness of Instruction-Following Models for Question Answering](https://mlsanity.com/paper/2307.16877/) (2023)
- [Towards Accurate Differential Diagnosis with Large Language Models](https://mlsanity.com/paper/2312.00164/) (2023)
- [Attributed Question Answering: Evaluation and Modeling for Attributed Large Language Models](https://mlsanity.com/paper/2212.08037/) (2022)
- [MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs](https://mlsanity.com/paper/2504.00993/) (2025)
- [Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions](https://mlsanity.com/paper/2402.18060/) (2024)
- [ContextCite: Attributing Model Generation to Context](https://mlsanity.com/paper/2409.00729/) (2024)
- [What is Your Data Worth to GPT? LLM-Scale Data Valuation with Influence Functions](https://mlsanity.com/paper/2405.13954/) (2024)
- [Towards Human-centered Explainable AI: A Survey of User Studies for Model Explanations](https://mlsanity.com/paper/2210.11584/) (2022)
- [Diagnostic Reasoning Prompts Reveal the Potential for Large Language Model Interpretability in Medicine](https://mlsanity.com/paper/2308.06834/) (2023)
- [Clinical Camel: An Open Expert-Level Medical Language Model with Dialogue-Based Knowledge Encoding](https://mlsanity.com/paper/2305.12031/) (2023)
- [CARES: A Comprehensive Benchmark of Trustworthiness in Medical Vision Language Models](https://mlsanity.com/paper/2406.06007/) (2024)
- [Baleen: Robust Multi-Hop Reasoning at Scale via Condensed Retrieval](https://mlsanity.com/paper/2101.00436/) (2021)
- [Relevance of Unsupervised Metrics in Task-Oriented Dialogue for Evaluating Natural Language Generation](https://mlsanity.com/paper/1706.09799/) (2017)

## Built on by (most cited first, 5 of 5)

- [Automating SKILL.md Generation for Computer-Using Agents via Interaction Trajectory Mining](https://mlsanity.com/paper/2606.20363/) (2026)
- [Chain of Risk: Safety Failures in Large Reasoning Models and Mitigation via Adaptive Multi-Principle Steering](https://mlsanity.com/paper/2605.05678/) (2026)
- [Treatment, evidence, imitation, and chat](https://mlsanity.com/paper/2506.23040/) (2025)
- [Counting Clues: A Lightweight Probabilistic Baseline Can Match an LLM](https://mlsanity.com/paper/2512.12868/) (2025)
- [ActiveMedAgent: Cost-Aware Trajectory Learning for Multimodal Medical Diagnosis](https://mlsanity.com/paper/2610.11140/) (2026)

## Abstract (arXiv)

Large Language Models (LLMs) have demonstrated remarkable performance on various medical question-answering (QA) benchmarks, including standardized medical exams. However, correct answers alone do not ensure correct logic, and models may reach accurate conclusions through flawed processes. In this study, we introduce the MedPAIR (Medical Dataset Comparing Physicians and AI Relevance Estimation and Question Answering) dataset to evaluate how physician trainees and LLMs prioritize relevant information when answering QA questions. We obtain annotations on 1,300 QA pairs from 36 physician trainees, labeling each sentence within the question components for relevance. We compare these relevance estimates to those for LLMs, and further evaluate the impact of these "relevant" subsets on downstream task performance for both physician trainees and LLMs. We find that LLMs are frequently not aligned with the content relevance estimates of physician trainees. After filtering out physician trainee-labeled irrelevant sentences, accuracy improves for both the trainees and the LLMs. All LLM and physician trainee-labeled data are available at: http://medpair.csail.mit.edu/.