# BiBLDR: Bidirectional Behavior Learning for Drug Repositioning

arXiv: https://arxiv.org/abs/2505.23861 · HTML: https://mlsanity.com/paper/2505.23861/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 69 references that are in the map.
- First posted on arXiv 29 May 2025.

## Builds on (most cited first, 9 of 9)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [BERT4Rec: Sequential Recommendation with Bidirectional Encoder Representations from Transformer](https://mlsanity.com/paper/1904.06690/) (2019)
- [DeepFM: A Factorization-Machine based Neural Network for CTR Prediction](https://mlsanity.com/paper/1703.04247/) (2017)
- [Behavior Sequence Transformer for E-commerce Recommendation in Alibaba](https://mlsanity.com/paper/1905.06874/) (2019)
- [A Survey of Graph Neural Networks for Social Recommender Systems](https://mlsanity.com/paper/2212.04481/) (2022)
- [Personalized Behavior-Aware Transformer for Multi-Behavior Sequential Recommendation](https://mlsanity.com/paper/2402.14473/) (2024)

## Abstract (arXiv)

Drug repositioning aims to identify potential new indications for existing drugs to reduce the time and financial costs associated with developing new drugs. Most existing deep learning-based drug repositioning methods predominantly utilize graph-based representations. However, graph-based drug repositioning methods struggle to perform effective inference in cold-start scenarios involving novel drugs because of the lack of association information with the diseases. Unlike traditional graph-based approaches, we propose a bidirectional behavior learning strategy for drug repositioning, known as BiBLDR. This innovative framework redefines drug repositioning as a behavior sequential learning task to capture drug-disease interaction patterns. First, we construct bidirectional behavioral sequences based on drug and disease sides. The consideration of bidirectional information ensures a more meticulous and rigorous characterization of the behavioral sequences. Subsequently, we propose a two-stage strategy for drug repositioning. In the first stage, we construct prototype spaces to characterize the representational attributes of drugs and diseases. In the second stage, these refined prototypes and bidirectional behavior sequence data are leveraged to predict potential drug-disease associations. Based on this learning approach, the model can more robustly and precisely capture the interactive relationships between drug and disease features from bidirectional behavioral sequences. Extensive experiments demonstrate that our method achieves state-of-the-art performance on benchmark datasets. Meanwhile, BiBLDR demonstrates significantly superior performance compared to previous methods in cold-start scenarios. Our code is published in https://github.com/Renyeeah/BiBLDR.