# Speech as a Multimodal Digital Phenotype for Multi-Task LLM-based Mental Health Prediction

arXiv: https://arxiv.org/abs/2505.23822 · HTML: https://mlsanity.com/paper/2505.23822/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 27 references that are in the map.
- First posted on arXiv 28 May 2025.

## Builds on (most cited first, 11 of 11)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [GPT Understands, Too](https://mlsanity.com/paper/2103.10385/) (2021)
- [AVEC 2019 Workshop and Challenge: State-of-Mind, Detecting Depression with AI, and Cross-Cultural Affect Recognition](https://mlsanity.com/paper/1907.11510/) (2019)
- [Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data](https://mlsanity.com/paper/2307.14385/) (2023)
- [Multi-Task Learning for Mental Health using Social Media Text](https://mlsanity.com/paper/1712.03538/) (2017)
- [When LLMs Meets Acoustic Landmarks: An Efficient Approach to Integrate Speech into Large Language Models for Depression Detection](https://mlsanity.com/paper/2402.13276/) (2024)
- [Read, Diagnose and Chat: Towards Explainable and Interactive LLMs-Augmented Depression Detection in Social Media](https://mlsanity.com/paper/2305.05138/) (2023)
- [DEPAC: a Corpus for Depression and Anxiety Detection from Speech](https://mlsanity.com/paper/2306.12443/) (2023)
- [The relationship between linguistic expression and symptoms of depression, anxiety, and suicidal thoughts: A longitudinal study of blog content](https://mlsanity.com/paper/1811.02750/) (2018)

## Built on by (most cited first, 2 of 2)

- [Evidence-Bounded Mental Health Reasoning from Heterogeneous Speech Protocols](https://mlsanity.com/paper/2608.31014/) (2026)
- [From Pattern Recognizers to Personalized Companions: A Survey of Large Language Models in Mental Health](https://mlsanity.com/paper/2609.25186/) (2026)

## Abstract (arXiv)

Speech is a noninvasive digital phenotype that can offer valuable insights into mental health conditions, but it is often treated as a single modality. In contrast, we propose the treatment of patient speech data as a trimodal multimedia data source for depression detection. This study explores the potential of large language model-based architectures for speech-based depression prediction in a multimodal regime that integrates speech-derived text, acoustic landmarks, and vocal biomarkers. Adolescent depression presents a significant challenge and is often comorbid with multiple disorders, such as suicidal ideation and sleep disturbances. This presents an additional opportunity to integrate multi-task learning (MTL) into our study by simultaneously predicting depression, suicidal ideation, and sleep disturbances using the multimodal formulation. We also propose a longitudinal analysis strategy that models temporal changes across multiple clinical interactions, allowing for a comprehensive understanding of the conditions' progression. Our proposed approach, featuring trimodal, longitudinal MTL is evaluated on the Depression Early Warning dataset. It achieves a balanced accuracy of 70.8%, which is higher than each of the unimodal, single-task, and non-longitudinal methods.