# ZeroSep: Separate Anything in Audio with Zero Training

arXiv: https://arxiv.org/abs/2505.23625 · HTML: https://mlsanity.com/paper/2505.23625/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Audio, speech and music, one of 14 directions in Diffusion models.
- Builds on 48 of its 56 references that are in the map.
- First posted on arXiv 29 May 2025.

## Placed in

- Diffusion models / [Audio, speech and music](https://mlsanity.com/diffusion/audio-speech-and-music/)

## Builds on (most cited first, 30 of 48)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [DiffWave: A Versatile Diffusion Model for Audio Synthesis](https://mlsanity.com/paper/2009.09761/) (2020)
- [High Fidelity Neural Audio Compression](https://mlsanity.com/paper/2210.13438/) (2022)
- [WaveGrad: Estimating Gradients for Waveform Generation](https://mlsanity.com/paper/2009.00713/) (2020)
- [AudioLDM: Text-to-Audio Generation with Latent Diffusion Models](https://mlsanity.com/paper/2301.12503/) (2023)
- [Erasing Concepts from Diffusion Models](https://mlsanity.com/paper/2303.07345/) (2023)
- [Grad-TTS: A Diffusion Probabilistic Model for Text-to-Speech](https://mlsanity.com/paper/2105.06337/) (2021)
- [Conv-TasNet: Surpassing Ideal Time-Frequency Magnitude Masking for Speech Separation](https://mlsanity.com/paper/1809.07454/) (2018)
- [AudioLDM 2: Learning Holistic Audio Generation with Self-supervised Pretraining](https://mlsanity.com/paper/2308.05734/) (2023)
- [The Sound of Pixels](https://mlsanity.com/paper/1804.03160/) (2018)
- [An Edit Friendly DDPM Noise Space: Inversion and Manipulations](https://mlsanity.com/paper/2304.06140/) (2023)
- [Fr'echet Audio Distance: A Metric for Evaluating Music Enhancement Algorithms](https://mlsanity.com/paper/1812.08466/) (2018)
- [Deep clustering: Discriminative embeddings for segmentation and separation](https://mlsanity.com/paper/1508.04306/) (2015)
- [Listen, Think, and Understand](https://mlsanity.com/paper/2305.10790/) (2023)
- [Stable Audio Open](https://mlsanity.com/paper/2407.14358/) (2024)
- [Permutation Invariant Training of Deep Models for Speaker-Independent Multi-talker Speech Separation](https://mlsanity.com/paper/1607.00325/) (2016)
- [Attention is All You Need in Speech Separation](https://mlsanity.com/paper/2010.13154/) (2020)
- [Localizing Visual Sounds the Hard Way](https://mlsanity.com/paper/2104.02691/) (2021)
- [Diff-TTS: A Denoising Diffusion Model for Text-to-Speech](https://mlsanity.com/paper/2104.01409/) (2021)
- [GAMA: A Large Audio-Language Model with Advanced Audio Understanding and Complex Reasoning Abilities](https://mlsanity.com/paper/2406.11768/) (2024)
- [DiffSinger: Singing Voice Synthesis via Shallow Diffusion Mechanism](https://mlsanity.com/paper/2105.02446/) (2021)
- [Concept Sliders: LoRA Adaptors for Precise Control in Diffusion Models](https://mlsanity.com/paper/2311.12092/) (2023)
- [Text-to-Audio Generation using Instruction-Tuned LLM and Latent Diffusion Model](https://mlsanity.com/paper/2304.13731/) (2023)
- [Eliminating Oversaturation and Artifacts of High Guidance Scales in Diffusion Models](https://mlsanity.com/paper/2410.02416/) (2024)
- [Guided-TTS: A Diffusion Model for Text-to-Speech via Classifier Guidance](https://mlsanity.com/paper/2111.11755/) (2021)
- [AUDIT: Audio Editing by Following Instructions with Latent Diffusion Models](https://mlsanity.com/paper/2304.00830/) (2023)

## Built on by (most cited first, 4 of 4)

- [SonoWorld: From One Image to a 3D Audio-Visual Scene](https://mlsanity.com/paper/2603.28757/) (2026)
- [High-Quality Sound Separation Across Diverse Categories via Visually-Guided Generative Modeling](https://mlsanity.com/paper/2509.22063/) (2025)
- [JAVEDIT: Joint Audio-Visual Instruction-Guided Video Editing with Agentic Data Curation](https://mlsanity.com/paper/2606.03168/) (2026)
- [MARS-Sep: Multimodal-Aligned Reinforced Sound Separation](https://mlsanity.com/paper/2510.10509/) (2025)

## Abstract (arXiv)

Audio source separation is fundamental for machines to understand complex acoustic environments and underpins numerous audio applications. Current supervised deep learning approaches, while powerful, are limited by the need for extensive, task-specific labeled data and struggle to generalize to the immense variability and open-set nature of real-world acoustic scenes. Inspired by the success of generative foundation models, we investigate whether pre-trained text-guided audio diffusion models can overcome these limitations. We make a surprising discovery: zero-shot source separation can be achieved purely through a pre-trained text-guided audio diffusion model under the right configuration. Our method, named ZeroSep, works by inverting the mixed audio into the diffusion model's latent space and then using text conditioning to guide the denoising process to recover individual sources. Without any task-specific training or fine-tuning, ZeroSep repurposes the generative diffusion model for a discriminative separation task and inherently supports open-set scenarios through its rich textual priors. ZeroSep is compatible with a variety of pre-trained text-guided audio diffusion backbones and delivers strong separation performance on multiple separation benchmarks, surpassing even supervised methods.