# MAMBO-NET: Multi-Causal Aware Modeling Backdoor-Intervention Optimization for Medical Image Segmentation Network

arXiv: https://arxiv.org/abs/2505.21874 · HTML: https://mlsanity.com/paper/2505.21874/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 22 of its 38 references that are in the map.
- First posted on arXiv 28 May 2025.

## Builds on (most cited first, 22 of 22)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [UNeXt: MLP-based Rapid Medical Image Segmentation Network](https://mlsanity.com/paper/2203.04967/) (2022)
- [Deconfounded Image Captioning: A Causal Retrospect](https://mlsanity.com/paper/2003.03923/) (2020)
- [AAU-net: An Adaptive Attention U-net for Breast Lesions Segmentation in Ultrasound Images](https://mlsanity.com/paper/2204.12077/) (2022)
- [BayeSeg: Bayesian Modeling for Medical Image Segmentation with Interpretable Generalizability](https://mlsanity.com/paper/2303.01710/) (2023)
- [ACC-UNet: A Completely Convolutional UNet model for the 2020s](https://mlsanity.com/paper/2308.13680/) (2023)
- [Global Guidance Network for Breast Lesion Segmentation in Ultrasound Images](https://mlsanity.com/paper/2104.01896/) (2021)
- [CDDSA: Contrastive Domain Disentanglement and Style Augmentation for Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2211.12081/) (2022)
- [CausalCLIPSeg: Unlocking CLIP's Potential in Referring Medical Image Segmentation with Causal Intervention](https://mlsanity.com/paper/2503.15949/) (2025)
- [EffiSegNet: Gastrointestinal Polyp Segmentation through a Pre-Trained EfficientNet-based Network with a Simplified Decoder](https://mlsanity.com/paper/2407.16298/) (2024)
- [Bilateral Asymmetry Guided Counterfactual Generating Network for Mammogram Classification](https://mlsanity.com/paper/2009.14406/) (2020)
- [Rethinking Radiology Report Generation via Causal Inspired Counterfactual Augmentation](https://mlsanity.com/paper/2311.13307/) (2023)
- [ProCNS: Progressive Prototype Calibration and Noise Suppression for Weakly-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2401.14074/) (2024)
- [Joint Segmentation and Deconvolution of Ultrasound Images Using a Hierarchical Bayesian Model based on Generalized Gaussian Priors](https://mlsanity.com/paper/1412.2813/) (2014)

## Built on by (most cited first, 1 of 1)

- [CAPRI-CT: Causal Analysis and Predictive Reasoning for Image Quality Optimization in Computed Tomography](https://mlsanity.com/paper/2507.17420/) (2025)

## Abstract (arXiv)

Medical image segmentation methods generally assume that the process from medical image to segmentation is unbiased, and use neural networks to establish conditional probability models to complete the segmentation task. This assumption does not consider confusion factors, which can affect medical images, such as complex anatomical variations and imaging modality limitations. Confusion factors obfuscate the relevance and causality of medical image segmentation, leading to unsatisfactory segmentation results. To address this issue, we propose a multi-causal aware modeling backdoor-intervention optimization (MAMBO-NET) network for medical image segmentation. Drawing insights from causal inference, MAMBO-NET utilizes self-modeling with multi-Gaussian distributions to fit the confusion factors and introduce causal intervention into the segmentation process. Moreover, we design appropriate posterior probability constraints to effectively train the distributions of confusion factors. For the distributions to effectively guide the segmentation and mitigate and eliminate the Impact of confusion factors on the segmentation, we introduce classical backdoor intervention techniques and analyze their feasibility in the segmentation task. To evaluate the effectiveness of our approach, we conducted extensive experiments on five medical image datasets. The results demonstrate that our method significantly reduces the influence of confusion factors, leading to enhanced segmentation accuracy.