# Optimizing Deep Learning for Skin Cancer Classification: A Computationally Efficient CNN with Minimal Accuracy Trade-Off

arXiv: https://arxiv.org/abs/2505.21597 · HTML: https://mlsanity.com/paper/2505.21597/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 4 of its 29 references that are in the map.
- First posted on arXiv 27 May 2025.

## Builds on (most cited first, 4 of 4)

- [Run, Don't Walk: Chasing Higher FLOPS for Faster Neural Networks](https://mlsanity.com/paper/2303.03667/) (2023)
- [GAN-Based Data Augmentation and Anonymization for Skin-Lesion Analysis: A Critical Review](https://mlsanity.com/paper/2104.10603/) (2021)
- [Automated Skin Lesion Classification Using Ensemble of Deep Neural Networks in ISIC 2018: Skin Lesion Analysis Towards Melanoma Detection Challenge](https://mlsanity.com/paper/1901.10802/) (2019)
- [FALCON: FLOP-Aware Combinatorial Optimization for Neural Network Pruning](https://mlsanity.com/paper/2403.07094/) (2024)

## Abstract (arXiv)

The rapid advancement of deep learning in medical image analysis has greatly enhanced the accuracy of skin cancer classification. However, current state-of-the-art models, especially those based on transfer learning like ResNet50, come with significant computational overhead, rendering them impractical for deployment in resource-constrained environments. This study proposes a custom CNN model that achieves a 96.7% reduction in parameters (from 23.9 million in ResNet50 to 692,000) while maintaining a classification accuracy deviation of less than 0.022%. Our empirical analysis of the HAM10000 dataset reveals that although transfer learning models provide a marginal accuracy improvement of approximately 0.022%, they result in a staggering 13,216.76% increase in FLOPs, considerably raising computational costs and inference latency. In contrast, our lightweight CNN architecture, which encompasses only 30.04 million FLOPs compared to ResNet50's 4.00 billion, significantly reduces energy consumption, memory footprint, and inference time. These findings underscore the trade-off between the complexity of deep models and their real-world feasibility, positioning our optimized CNN as a practical solution for mobile and edge-based skin cancer diagnostics.