# FMEnets: Flow, Material, and Energy networks for non-ideal plug flow reactor design

arXiv: https://arxiv.org/abs/2505.20300 · HTML: https://mlsanity.com/paper/2505.20300/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 34 of its 83 references that are in the map.
- First posted on arXiv 10 May 2025.

## Builds on (most cited first, 30 of 34)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [KAN: Kolmogorov-Arnold Networks](https://mlsanity.com/paper/2404.19756/) (2024)
- [Characterizing possible failure modes in physics-informed neural networks](https://mlsanity.com/paper/2109.01050/) (2021)
- [When and why PINNs fail to train: A neural tangent kernel perspective](https://mlsanity.com/paper/2007.14527/) (2020)
- [DeepXDE: A deep learning library for solving differential equations](https://mlsanity.com/paper/1907.04502/) (2019)
- [Scientific Machine Learning through Physics-Informed Neural Networks: Where we are and What's next](https://mlsanity.com/paper/2201.05624/) (2022)
- [Weight Normalization: A Simple Reparameterization to Accelerate Training of Deep Neural Networks](https://mlsanity.com/paper/1602.07868/) (2016)
- [Learning the solution operator of parametric partial differential equations with physics-informed DeepOnets](https://mlsanity.com/paper/2103.10974/) (2021)
- [Physics-informed neural networks (PINNs) for fluid mechanics: A review](https://mlsanity.com/paper/2105.09506/) (2021)
- [Machine Learning for Fluid Mechanics](https://mlsanity.com/paper/1905.11075/) (2019)
- [Physics-informed neural networks with hard constraints for inverse design](https://mlsanity.com/paper/2102.04626/) (2021)
- [A comprehensive study of non-adaptive and residual-based adaptive sampling for physics-informed neural networks](https://mlsanity.com/paper/2207.10289/) (2022)
- [Self-Adaptive Physics-Informed Neural Networks using a Soft Attention Mechanism](https://mlsanity.com/paper/2009.04544/) (2020)
- [Respecting causality is all you need for training physics-informed neural networks](https://mlsanity.com/paper/2203.07404/) (2022)
- [Exact imposition of boundary conditions with distance functions in physics-informed deep neural networks](https://mlsanity.com/paper/2104.08426/) (2021)
- [An Expert's Guide to Training Physics-informed Neural Networks](https://mlsanity.com/paper/2308.08468/) (2023)
- [Challenges in Training PINNs: A Loss Landscape Perspective](https://mlsanity.com/paper/2402.01868/) (2024)
- [A comprehensive and FAIR comparison between MLP and KAN representations for differential equations and operator networks](https://mlsanity.com/paper/2406.02917/) (2024)
- [Physics-Informed Machine Learning: A Survey on Problems, Methods and Applications](https://mlsanity.com/paper/2211.08064/) (2022)
- [A Method for Representing Periodic Functions and Enforcing Exactly Periodic Boundary Conditions with Deep Neural Networks](https://mlsanity.com/paper/2007.07442/) (2020)
- [From PINNs to PIKANs: Recent Advances in Physics-Informed Machine Learning](https://mlsanity.com/paper/2410.13228/) (2024)
- [Residual-based attention in physics-informed neural networks](https://mlsanity.com/paper/2307.00379/) (2023)
- [PirateNets: Physics-informed Deep Learning with Residual Adaptive Networks](https://mlsanity.com/paper/2402.00326/) (2024)
- [A Dual-Dimer Method for Training Physics-Constrained Neural Networks with Minimax Architecture](https://mlsanity.com/paper/2005.00615/) (2020)
- [AI-Aristotle: A Physics-Informed framework for Systems Biology Gray-Box Identification](https://mlsanity.com/paper/2310.01433/) (2023)
- [Investigating molecular transport in the human brain from MRI with physics-informed neural networks](https://mlsanity.com/paper/2205.02592/) (2022)
- [Systems Biology: Identifiability analysis and parameter identification via systems-biology informed neural networks](https://mlsanity.com/paper/2202.01723/) (2022)
- [Investigating and Mitigating Failure Modes in Physics-informed Neural Networks (PINNs)](https://mlsanity.com/paper/2209.09988/) (2022)
- [Inferring turbulent velocity and temperature fields and their statistics from Lagrangian velocity measurements using physics-informed Kolmogorov-Arnold Networks](https://mlsanity.com/paper/2407.15727/) (2024)
- [Learning in PINNs: Phase transition, diffusion equilibrium, and generalization](https://mlsanity.com/paper/2403.18494/) (2024)

## Built on by (most cited first, 2 of 2)

- [ATHENA: Agentic Team for Hierarchical Evolutionary Numerical Algorithms](https://mlsanity.com/paper/2512.03476/) (2025)
- [A Variational Framework for Residual-Based Adaptivity in Neural PDE Solvers and Operator Learning](https://mlsanity.com/paper/2509.14198/) (2025)

## Abstract (arXiv)

We propose FMEnets, a physics-informed machine learning framework for the design and analysis of non-ideal plug flow reactors. FMEnets integrates the fundamental governing equations (Navier-Stokes for fluid flow, material balance for reactive species transport, and energy balance for temperature distribution) into a unified multi-scale network model. The framework is composed of three interconnected sub-networks with independent optimizers that enable both forward and inverse problem-solving. In the forward mode, FMEnets predicts velocity, pressure, species concentrations, and temperature profiles using only inlet and outlet information. In the inverse mode, FMEnets utilizes sparse multi-residence-time measurements to simultaneously infer unknown kinetic parameters and states. FMEnets can be implemented either as FME-PINNs, which employ conventional multilayer perceptrons, or as FME-KANs, based on Kolmogorov-Arnold Networks. Comprehensive ablation studies highlight the critical role of the FMEnets architecture in achieving accurate predictions. Specifically, FME-KANs are more robust to noise than FME-PINNs, although both representations are comparable in accuracy and speed in noise-free conditions. The proposed framework is applied to three different sets of reaction scenarios and is compared with finite element simulations. FMEnets effectively captures the complex interactions, achieving relative errors less than 2.5% for the unknown kinetic parameters. The new network framework not only provides a computationally efficient alternative for reactor design and optimization, but also opens new avenues for integrating empirical correlations, limited and noisy experimental data, and fundamental physical equations to guide reactor design.