# InternAgent: When Agent Becomes the Scientist -- Building Closed-Loop System from Hypothesis to Verification

arXiv: https://arxiv.org/abs/2505.16938 · HTML: https://mlsanity.com/paper/2505.16938/

## Key facts

- Cited by 46 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 22 May 2025.

## Built on by (most cited first, 30 of 46)

- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [A Survey of Agent Memory in the Second Half: Towards Self-Evolving and Long-Horizon Agents](https://mlsanity.com/paper/2602.06052/) (2026)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [InternAgent-1.5: A Unified Agentic Framework for Long-Horizon Autonomous Scientific Discovery](https://mlsanity.com/paper/2602.08990/) (2026)
- [MARS: Modular Agent with Reflective Search for Automated AI Research](https://mlsanity.com/paper/2602.02660/) (2026)
- [ResearchGym: Evaluating Language Model Agents on Real-World AI Research](https://mlsanity.com/paper/2602.15112/) (2026)
- [The FM Agent](https://mlsanity.com/paper/2510.26144/) (2025)
- [InnovatorBench: Evaluating Agents' Ability to Conduct Innovative LLM Research](https://mlsanity.com/paper/2510.27598/) (2025)
- [AutoLabs: Cognitive Multi-Agent Systems with Self-Correction for Autonomous Chemical Experimentation](https://mlsanity.com/paper/2509.25651/) (2025)
- [PaperOrchestra: A Multi-Agent Framework for Automated AI Research Paper Writing](https://mlsanity.com/paper/2604.05018/) (2026)
- [AIBuildAI: An AI Agent for Automatically Building AI Models](https://mlsanity.com/paper/2604.14455/) (2026)
- [KAPSO: A Knowledge-grounded framework for Autonomous Program Synthesis and Optimization](https://mlsanity.com/paper/2601.21526/) (2026)
- [AI for Auto-Research: Roadmap & User Guide](https://mlsanity.com/paper/2605.18661/) (2026)
- [Can We Predict Before Executing Machine Learning Agents?](https://mlsanity.com/paper/2601.05930/) (2026)
- [Evolving Roles of LLMs in Scientific Innovation: Assistant, Collaborator, Scientist, and Evaluator](https://mlsanity.com/paper/2507.11810/) (2025)
- [Autonomous Research Agents: A Survey of AI Scientists and the Verification Gap](https://mlsanity.com/paper/2608.05179/) (2026)
- [InnoEval: On Research Idea Evaluation as a Knowledge-Grounded, Multi-Perspective Reasoning Problem](https://mlsanity.com/paper/2602.14367/) (2026)
- [Self-Improvement of Large Language Models: A Technical Overview and Future Outlook](https://mlsanity.com/paper/2603.25681/) (2026)
- [Perspectra: Choosing Your Experts Enhances Critical Thinking in Multi-Agent Research Ideation](https://mlsanity.com/paper/2509.20553/) (2025)
- [Milestones over Outcome: Unlocking Geometric Reasoning with Sub-Goal Verifiable Reward](https://mlsanity.com/paper/2601.05073/) (2026)
- [S1-NexusAgent: a Self-Evolving Agent Framework for Multidisciplinary Scientific Research](https://mlsanity.com/paper/2602.01550/) (2026)
- [SciDataCopilot: An Agentic Data Preparation Framework for AGI-driven Scientific Discovery](https://mlsanity.com/paper/2602.09132/) (2026)
- [NanoResearch: Co-Evolving Skills, Memory, and Policy for Personalized Research Automation](https://mlsanity.com/paper/2605.10813/) (2026)
- [Agon: An Autonomous Large-Scale Omnidisciplinary Research System Built on Prompt Economy](https://mlsanity.com/paper/2606.24177/) (2026)
- [ScienceFlow: A long-horizon agent for ML research, scientific discovery and beyond](https://mlsanity.com/paper/2608.14354/) (2026)
- [ReX-MLE: The Autonomous Agent Benchmark for Medical Imaging Challenges](https://mlsanity.com/paper/2512.17838/) (2025)
- [AIBuildAI-2: A Knowledge-Enhanced Agent for Automatically Building AI Models](https://mlsanity.com/paper/2605.27873/) (2026)
- [Agents-K1: Towards Agent-native Knowledge Orchestration](https://mlsanity.com/paper/2606.13669/) (2026)
- [Multi-agent discovery of practical quantum LDPC codes](https://mlsanity.com/paper/2608.08996/) (2026)

## Abstract (arXiv)

Artificial Intelligence (AI) is accelerating the transformation of scientific research paradigms, not only enhancing research efficiency but also driving innovation. We introduce InternAgent, a unified closed-loop multi-agent framework to conduct Autonomous Scientific Research (ASR) across various scientific research fields, enabling researchers to tackle complicated problems in these fields with unprecedented speed and precision. InternAgent highlights three key advantages: 1) Scalability: InternAgent has demonstrated its versatility across 12 scientific research tasks, capable of generating innovative ideas to enhance the performance of baseline code. 2) Interactivity: InternAgent provides an interface for human expert feedback and multi-agent interaction in automated end-to-end processes, allowing for the seamless integration of domain expert knowledge. 3) Efficiency: InternAgent has achieved promising performance gains in several scientific fields with significantly less time cost compared to human efforts. For instance, in reaction yield prediction, it increased from 27.6% to 35.4% in just 12 hours; in enhancer activity prediction, accuracy rose from 0.65 to 0.79 with only 4 hours of processing; and in 2D semantic segmentation, precision advanced from 78.8% to 81.0% in a mere 30 hours.