# Hypergraph Tversky-Aware Domain Incremental Learning for Brain Tumor Segmentation with Missing Modalities

arXiv: https://arxiv.org/abs/2505.16809 · HTML: https://mlsanity.com/paper/2505.16809/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 30 references that are in the map.
- First posted on arXiv 22 May 2025.

## Builds on (most cited first, 13 of 13)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [mmFormer: Multimodal Medical Transformer for Incomplete Multimodal Learning of Brain Tumor Segmentation](https://mlsanity.com/paper/2206.02425/) (2022)
- [M3AE: Multimodal Representation Learning for Brain Tumor Segmentation with Missing Modalities](https://mlsanity.com/paper/2303.05302/) (2023)
- [Latent Correlation Representation Learning for Brain Tumor Segmentation with Missing MRI Modalities](https://mlsanity.com/paper/2104.06231/) (2021)
- [A Survey on Continual Semantic Segmentation: Theory, Challenge, Method and Application](https://mlsanity.com/paper/2310.14277/) (2023)
- [PASSION: Towards Effective Incomplete Multi-Modal Medical Image Segmentation with Imbalanced Missing Rates](https://mlsanity.com/paper/2407.14796/) (2024)
- [Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentation](https://mlsanity.com/paper/2503.12068/) (2025)
- [GrainSpace: A Large-scale Dataset for Fine-grained and Domain-adaptive Recognition of Cereal Grains](https://mlsanity.com/paper/2203.05306/) (2022)
- [Improving Replay-Based Continual Semantic Segmentation with Smart Data Selection](https://mlsanity.com/paper/2209.09839/) (2022)
- [Approximate Equivariance SO(3) Needlet Convolution](https://mlsanity.com/paper/2206.10385/) (2022)
- [Anatomical Consistency Distillation and Inconsistency Synthesis for Brain Tumor Segmentation with Missing Modalities](https://mlsanity.com/paper/2408.13733/) (2024)

## Built on by (most cited first, 7 of 7)

- [ModAn-MulSupCon: Modality-and Anatomy-Aware Multi-Label Supervised Contrastive Pretraining for Medical Imaging](https://mlsanity.com/paper/2508.18613/) (2025)
- [Cross-Stain Contrastive Learning for Paired Immunohistochemistry and Histopathology Slide Representation Learning](https://mlsanity.com/paper/2512.03577/) (2025)
- [Harnessing Hypergraphs in Geometric Deep Learning for 3D RNA Inverse Folding](https://mlsanity.com/paper/2512.03592/) (2025)
- [SHAPE: Structure-aware Hierarchical Unsupervised Domain Adaptation with Plausibility Evaluation for Medical Image Segmentation](https://mlsanity.com/paper/2603.21904/) (2026)
- [Virtual Nodes Guided Dynamic Graph Neural Network for Brain Tumor Segmentation with Missing Modalities](https://mlsanity.com/paper/2605.16880/) (2026)
- [D3Seg: Dependency-Aware Diffusion for Brain Tumor Segmentation with Missing Modalities](https://mlsanity.com/paper/2605.22249/) (2026)
- [Projection-Domain Sensitivity Analysis of Vertebral DRRs Under Intrinsic Calibration Perturbation](https://mlsanity.com/paper/2607.10551/) (2026)

## Abstract (arXiv)

Existing methods for multimodal MRI segmentation with missing modalities typically assume that all MRI modalities are available during training. However, in clinical practice, some modalities may be missing due to the sequential nature of MRI acquisition, leading to performance degradation. Furthermore, retraining models to accommodate newly available modalities can be inefficient and may cause overfitting, potentially compromising previously learned knowledge. To address these challenges, we propose Replay-based Hypergraph Domain Incremental Learning (ReHyDIL) for brain tumor segmentation with missing modalities. ReHyDIL leverages Domain Incremental Learning (DIL) to enable the segmentation model to learn from newly acquired MRI modalities without forgetting previously learned information. To enhance segmentation performance across diverse patient scenarios, we introduce the Cross-Patient Hypergraph Segmentation Network (CHSNet), which utilizes hypergraphs to capture high-order associations between patients. Additionally, we incorporate Tversky-Aware Contrastive (TAC) loss to effectively mitigate information imbalance both across and within different modalities. Extensive experiments on the BraTS2019 dataset demonstrate that ReHyDIL outperforms state-of-the-art methods, achieving an improvement of over 2% in the Dice Similarity Coefficient across various tumor regions. Our code is available at https://github.com/reeive/ReHyDIL.