# CMRINet: Joint Groupwise Registration and Segmentation for Cardiac Function Quantification from Cine-MRI

arXiv: https://arxiv.org/abs/2505.16452 · HTML: https://mlsanity.com/paper/2505.16452/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 56 references that are in the map.
- First posted on arXiv 22 May 2025.

## Builds on (most cited first, 16 of 16)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [A Deep Learning Framework for Unsupervised Affine and Deformable Image Registration](https://mlsanity.com/paper/1809.06130/) (2018)
- [Deep learning for cardiac image segmentation: A review](https://mlsanity.com/paper/1911.03723/) (2019)
- [SegFlow: Joint Learning for Video Object Segmentation and Optical Flow](https://mlsanity.com/paper/1709.06750/) (2017)
- [Combo Loss: Handling Input and Output Imbalance in Multi-Organ Segmentation](https://mlsanity.com/paper/1805.02798/) (2018)
- [Learning a Probabilistic Model for Diffeomorphic Registration](https://mlsanity.com/paper/1812.07460/) (2018)
- [Joint Learning of Motion Estimation and Segmentation for Cardiac MR Image Sequences](https://mlsanity.com/paper/1806.04066/) (2018)
- [Fully Convolutional Multi-scale Residual DenseNets for Cardiac Segmentation and Automated Cardiac Diagnosis using Ensemble of Classifiers](https://mlsanity.com/paper/1801.05173/) (2018)
- [Recurrent Fully Convolutional Neural Networks for Multi-slice MRI Cardiac Segmentation](https://mlsanity.com/paper/1608.03974/) (2016)
- [GroupRegNet: A Groupwise One-shot Deep Learning-based 4D Image Registration Method](https://mlsanity.com/paper/2009.02613/) (2020)
- [Joint Registration and Segmentation via Multi-Task Learning for Adaptive Radiotherapy of Prostate Cancer](https://mlsanity.com/paper/2105.01844/) (2021)
- [Adversarial optimization for joint registration and segmentation in prostate CT radiotherapy](https://mlsanity.com/paper/1906.12223/) (2019)
- [Deep Learning Analysis of Cardiac MRI in Legacy Datasets: Multi-Ethnic Study of Atherosclerosis](https://mlsanity.com/paper/2110.15144/) (2021)

## Abstract (arXiv)

Accurate and efficient quantification of cardiac function is essential for the estimation of prognosis of cardiovascular diseases (CVDs). One of the most commonly used metrics for evaluating cardiac pumping performance is left ventricular ejection fraction (LVEF). However, LVEF can be affected by factors such as inter-observer variability and varying pre-load and after-load conditions, which can reduce its reproducibility. Additionally, cardiac dysfunction may not always manifest as alterations in LVEF, such as in heart failure and cardiotoxicity diseases. An alternative measure that can provide a relatively load-independent quantitative assessment of myocardial contractility is myocardial strain and strain rate. By using LVEF in combination with myocardial strain, it is possible to obtain a thorough description of cardiac function. Automated estimation of LVEF and other volumetric measures from cine-MRI sequences can be achieved through segmentation models, while strain calculation requires the estimation of tissue displacement between sequential frames, which can be accomplished using registration models. These tasks are often performed separately, potentially limiting the assessment of cardiac function. To address this issue, in this study we propose an end-to-end deep learning (DL) model that jointly estimates groupwise (GW) registration and segmentation for cardiac cine-MRI images. The proposed anatomically-guided Deep GW network was trained and validated on a large dataset of 4-chamber view cine-MRI image series of 374 subjects. A quantitative comparison with conventional GW registration using elastix and two DL-based methods showed that the proposed model improved performance and substantially reduced computation time.