# Domain Adaptive Skin Lesion Classification via Conformal Ensemble of Vision Transformers

arXiv: https://arxiv.org/abs/2505.15997 · HTML: https://mlsanity.com/paper/2505.15997/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 20 references that are in the map.
- First posted on arXiv 21 May 2025.

## Builds on (most cited first, 15 of 15)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Gentle Introduction to Conformal Prediction and Distribution-Free Uncertainty Quantification](https://mlsanity.com/paper/2107.07511/) (2021)
- [A Survey on Visual Transformer](https://mlsanity.com/paper/2012.12556/) (2020)
- [Uncertainty Sets for Image Classifiers using Conformal Prediction](https://mlsanity.com/paper/2009.14193/) (2020)
- [Domain Adaptive Ensemble Learning](https://mlsanity.com/paper/2003.07325/) (2020)
- [CDTrans: Cross-domain Transformer for Unsupervised Domain Adaptation](https://mlsanity.com/paper/2109.06165/) (2021)
- [Spectral Unsupervised Domain Adaptation for Visual Recognition](https://mlsanity.com/paper/2106.06112/) (2021)
- [Empirical Validation of Conformal Prediction for Trustworthy Skin Lesions Classification](https://mlsanity.com/paper/2312.07460/) (2023)
- [Empirically Validating Conformal Prediction on Modern Vision Architectures Under Distribution Shift and Long-tailed Data](https://mlsanity.com/paper/2307.01088/) (2023)
- [Making the Best of Both Worlds: A Domain-Oriented Transformer for Unsupervised Domain Adaptation](https://mlsanity.com/paper/2208.01195/) (2022)
- [SkinDistilViT: Lightweight Vision Transformer for Skin Lesion Classification](https://mlsanity.com/paper/2308.08669/) (2023)

## Abstract (arXiv)

Exploring the trustworthiness of deep learning models is crucial, especially in critical domains such as medical imaging decision support systems. Conformal prediction has emerged as a rigorous means of providing deep learning models with reliable uncertainty estimates and safety guarantees. However, conformal prediction results face challenges due to the backbone model's struggles in domain-shifted scenarios, such as variations in different sources. To aim this challenge, this paper proposes a novel framework termed Conformal Ensemble of Vision Transformers (CE-ViTs) designed to enhance image classification performance by prioritizing domain adaptation and model robustness, while accounting for uncertainty. The proposed method leverages an ensemble of vision transformer models in the backbone, trained on diverse datasets including HAM10000, Dermofit, and Skin Cancer ISIC datasets. This ensemble learning approach, calibrated through the combined mentioned datasets, aims to enhance domain adaptation through conformal learning. Experimental results underscore that the framework achieves a high coverage rate of 90.38%, representing an improvement of 9.95% compared to the HAM10000 model. This indicates a strong likelihood that the prediction set includes the true label compared to singular models. Ensemble learning in CE-ViTs significantly improves conformal prediction performance, increasing the average prediction set size for challenging misclassified samples from 1.86 to 3.075.