# P3Net: Progressive and Periodic Perturbation for Semi-Supervised Medical Image Segmentation

arXiv: https://arxiv.org/abs/2505.15861 · HTML: https://mlsanity.com/paper/2505.15861/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 41 of its 60 references that are in the map.
- First posted on arXiv 21 May 2025.

## Builds on (most cited first, 30 of 41)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Improved Regularization of Convolutional Neural Networks with Cutout](https://mlsanity.com/paper/1708.04552/) (2017)
- [MixMatch: A Holistic Approach to Semi-Supervised Learning](https://mlsanity.com/paper/1905.02249/) (2019)
- [YOLOX: Exceeding YOLO Series in 2021](https://mlsanity.com/paper/2107.08430/) (2021)
- [Temporal Ensembling for Semi-Supervised Learning](https://mlsanity.com/paper/1610.02242/) (2016)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [Semi-Supervised Semantic Segmentation with Cross-Consistency Training](https://mlsanity.com/paper/2003.09005/) (2020)
- [ReMixMatch: Semi-Supervised Learning with Distribution Alignment and Augmentation Anchoring](https://mlsanity.com/paper/1911.09785/) (2019)
- [Interpolation Consistency Training for Semi-Supervised Learning](https://mlsanity.com/paper/1903.03825/) (2019)
- [DACS: Domain Adaptation via Cross-domain Mixed Sampling](https://mlsanity.com/paper/2007.08702/) (2020)
- [Semi-supervised Medical Image Segmentation through Dual-task Consistency](https://mlsanity.com/paper/2009.04448/) (2020)
- [REMIND Your Neural Network to Prevent Catastrophic Forgetting](https://mlsanity.com/paper/1910.02509/) (2019)
- [Revisiting Weak-to-Strong Consistency in Semi-Supervised Semantic Segmentation](https://mlsanity.com/paper/2208.09910/) (2022)
- [DeepOrgan: Multi-level Deep Convolutional Networks for Automated Pancreas Segmentation](https://mlsanity.com/paper/1506.06448/) (2015)
- [Shape-aware Semi-supervised 3D Semantic Segmentation for Medical Images](https://mlsanity.com/paper/2007.10732/) (2020)
- [Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/1903.00348/) (2019)
- [Bidirectional Copy-Paste for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2305.00673/) (2023)
- [Perturbed and Strict Mean Teachers for Semi-supervised Semantic Segmentation](https://mlsanity.com/paper/2111.12903/) (2021)
- [Exploring Smoothness and Class-Separation for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2203.01324/) (2022)
- [Re-distributing Biased Pseudo Labels for Semi-supervised Semantic Segmentation: A Baseline Investigation](https://mlsanity.com/paper/2107.11279/) (2021)
- [Augmentation Matters: A Simple-yet-Effective Approach to Semi-supervised Semantic Segmentation](https://mlsanity.com/paper/2212.04976/) (2022)
- [Inconsistency-aware Uncertainty Estimation for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2110.08762/) (2021)
- [Enhancing Pseudo Label Quality for Semi-Supervised Domain-Generalized Medical Image Segmentation](https://mlsanity.com/paper/2201.08657/) (2022)
- [DSP: Dual Soft-Paste for Unsupervised Domain Adaptive Semantic Segmentation](https://mlsanity.com/paper/2107.09600/) (2021)
- [Local contrastive loss with pseudo-label based self-training for semi-supervised medical image segmentation](https://mlsanity.com/paper/2112.09645/) (2021)
- [Structured Consistency Loss for semi-supervised semantic segmentation](https://mlsanity.com/paper/2001.04647/) (2020)

## Abstract (arXiv)

Perturbation with diverse unlabeled data has proven beneficial for semi-supervised medical image segmentation (SSMIS). While many works have successfully used various perturbation techniques, a deeper understanding of learning perturbations is needed. Excessive or inappropriate perturbation can have negative effects, so we aim to address two challenges: how to use perturbation mechanisms to guide the learning of unlabeled data through labeled data, and how to ensure accurate predictions in boundary regions. Inspired by human progressive and periodic learning, we propose a progressive and periodic perturbation mechanism (P3M) and a boundary-focused loss. P3M enables dynamic adjustment of perturbations, allowing the model to gradually learn them. Our boundary-focused loss encourages the model to concentrate on boundary regions, enhancing sensitivity to intricate details and ensuring accurate predictions. Experimental results demonstrate that our method achieves state-of-the-art performance on two 2D and 3D datasets. Moreover, P3M is extendable to other methods, and the proposed loss serves as a universal tool for improving existing methods, highlighting the scalability and applicability of our approach.