# Lung Nodule-SSM: Self-Supervised Lung Nodule Detection and Classification in Thoracic CT Images

arXiv: https://arxiv.org/abs/2505.15120 · HTML: https://mlsanity.com/paper/2505.15120/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 44 references that are in the map.
- First posted on arXiv 21 May 2025.

## Builds on (most cited first, 11 of 11)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Self-Supervised Pre-Training of Swin Transformers for 3D Medical Image Analysis](https://mlsanity.com/paper/2111.14791/) (2021)
- [Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge](https://mlsanity.com/paper/1612.08012/) (2016)
- [Transparency of Deep Neural Networks for Medical Image Analysis: A Review of Interpretability Methods](https://mlsanity.com/paper/2111.02398/) (2021)
- [Parameter-Efficient Fine-Tuning for Foundation Models](https://mlsanity.com/paper/2501.13787/) (2025)
- [DeepLung: Deep 3D Dual Path Nets for Automated Pulmonary Nodule Detection and Classification](https://mlsanity.com/paper/1801.09555/) (2018)
- [Medical Image Segmentation with 3D Convolutional Neural Networks: A Survey](https://mlsanity.com/paper/2108.08467/) (2021)
- [Comparative Analysis of ImageNet Pre-Trained Deep Learning Models and DINOv2 in Medical Imaging Classification](https://mlsanity.com/paper/2402.07595/) (2024)

## Abstract (arXiv)

Lung cancer remains among the deadliest types of cancer in recent decades, and early lung nodule detection is crucial for improving patient outcomes. The limited availability of annotated medical imaging data remains a bottleneck in developing accurate computer-aided diagnosis (CAD) systems. Self-supervised learning can help leverage large amounts of unlabeled data to develop more robust CAD systems. With the recent advent of transformer-based architecture and their ability to generalize to unseen tasks, there has been an effort within the healthcare community to adapt them to various medical downstream tasks. Thus, we propose a novel "LungNodule-SSM" method, which utilizes selfsupervised learning with DINOv2 as a backbone to enhance lung nodule detection and classification without annotated data. Our methodology has two stages: firstly, the DINOv2 model is pre-trained on unlabeled CT scans to learn robust feature representations, then secondly, these features are fine-tuned using transformer-based architectures for lesionlevel detection and accurate lung nodule diagnosis. The proposed method has been evaluated on the challenging LUNA 16 dataset, consisting of 888 CT scans, and compared with SOTA methods. Our experimental results show the superiority of our proposed method with an accuracy of 98.37%, explaining its effectiveness in lung nodule detection. The source code, datasets, and pre-processed data can be accessed using the link:https://github.com/EMeRALDsNRPU/Lung-Nodule-SSM-Self-Supervised-Lung-Nodule-Detection-and-Classification/tree/main