# Advancing Multiple Instance Learning with Continual Learning for Whole Slide Imaging

arXiv: https://arxiv.org/abs/2505.10649 · HTML: https://mlsanity.com/paper/2505.10649/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 20 of its 29 references that are in the map.
- First posted on arXiv 15 May 2025.

## Builds on (most cited first, 20 of 20)

- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Learning without Forgetting](https://mlsanity.com/paper/1606.09282/) (2016)
- [Gradient Episodic Memory for Continual Learning](https://mlsanity.com/paper/1706.08840/) (2017)
- [Progressive Neural Networks](https://mlsanity.com/paper/1606.04671/) (2016)
- [Memory Aware Synapses: Learning what (not) to forget](https://mlsanity.com/paper/1711.09601/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Dark Experience for General Continual Learning: a Strong, Simple Baseline](https://mlsanity.com/paper/2004.07211/) (2020)
- [PackNet: Adding Multiple Tasks to a Single Network by Iterative Pruning](https://mlsanity.com/paper/1711.05769/) (2017)
- [A Comprehensive Survey of Continual Learning: Theory, Method and Application](https://mlsanity.com/paper/2302.00487/) (2023)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [Three scenarios for continual learning](https://mlsanity.com/paper/1904.07734/) (2019)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Learning to Learn without Forgetting by Maximizing Transfer and Minimizing Interference](https://mlsanity.com/paper/1810.11910/) (2018)
- [Nystr"omformer: A Nystr"om-Based Algorithm for Approximating Self-Attention](https://mlsanity.com/paper/2102.03902/) (2021)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [Attention-Challenging Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2311.07125/) (2023)
- [ConSlide: Asynchronous Hierarchical Interaction Transformer with Breakup-Reorganize Rehearsal for Continual Whole Slide Image Analysis](https://mlsanity.com/paper/2308.13324/) (2023)
- [Shapley Values-enabled Progressive Pseudo Bag Augmentation for Whole Slide Image Classification](https://mlsanity.com/paper/2312.05490/) (2023)
- [On Sequential Bayesian Inference for Continual Learning](https://mlsanity.com/paper/2301.01828/) (2023)
- [Domain Adaptive Multiple Instance Learning for Instance-level Prediction of Pathological Images](https://mlsanity.com/paper/2304.03537/) (2023)

## Built on by (most cited first, 1 of 1)

- [AINet: Anchor Instances Learning for Regional Heterogeneity in Whole Slide Image](https://mlsanity.com/paper/2602.20187/) (2026)

## Abstract (arXiv)

Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often lack adaptability to evolving datasets, as they rely on static training that cannot incorporate new information without extensive retraining. Applying continual learning (CL) to MIL models is a possible solution, but often sees limited improvements. In this paper, we analyze CL in the context of attention MIL models and find that the model forgetting is mainly concentrated in the attention layers of the MIL model. Using the results of this analysis we propose two components for improving CL on MIL: Attention Knowledge Distillation (AKD) and the Pseudo-Bag Memory Pool (PMP). AKD mitigates catastrophic forgetting by focusing on retaining attention layer knowledge between learning sessions, while PMP reduces the memory footprint by selectively storing only the most informative patches, or ``pseudo-bags'' from WSIs. Experimental evaluations demonstrate that our method significantly improves both accuracy and memory efficiency on diverse WSI datasets, outperforming current state-of-the-art CL methods. This work provides a foundation for CL in large-scale, weakly annotated clinical datasets, paving the way for more adaptable and resilient diagnostic models.