# Radiogenomic Bipartite Graph Representation Learning for Alzheimer's Disease Detection

arXiv: https://arxiv.org/abs/2505.09848 · HTML: https://mlsanity.com/paper/2505.09848/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 2 of its 28 references that are in the map.
- First posted on arXiv 14 May 2025.

## Builds on (most cited first, 2 of 2)

- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Graph Neural Networks: A Review of Methods and Applications](https://mlsanity.com/paper/1812.08434/) (2018)

## Abstract (arXiv)

Imaging and genomic data offer distinct and rich features, and their integration can unveil new insights into the complex landscape of diseases. In this study, we present a novel approach utilizing radiogenomic data including structural MRI images and gene expression data, for Alzheimer's disease detection. Our framework introduces a novel heterogeneous bipartite graph representation learning featuring two distinct node types: genes and images. The network can effectively classify Alzheimer's disease (AD) into three distinct stages:AD, Mild Cognitive Impairment (MCI), and Cognitive Normal (CN) classes, utilizing a small dataset. Additionally, it identified which genes play a significant role in each of these classification groups. We evaluate the performance of our approach using metrics including classification accuracy, recall, precision, and F1 score. The proposed technique holds potential for extending to radiogenomic-based classification to other diseases.