# Ophora: A Large-Scale Data-Driven Text-Guided Ophthalmic Surgical Video Generation Model

arXiv: https://arxiv.org/abs/2505.07449 · HTML: https://mlsanity.com/paper/2505.07449/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Builds on 21 of its 29 references that are in the map.
- First posted on arXiv 12 May 2025.

## Builds on (most cited first, 21 of 21)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Qwen2.5-VL Technical Report](https://mlsanity.com/paper/2502.13923/) (2025)
- [Qwen2.5 Technical Report](https://mlsanity.com/paper/2412.15115/) (2024)
- [CLIPScore: A Reference-free Evaluation Metric for Image Captioning](https://mlsanity.com/paper/2104.08718/) (2021)
- [CogVideoX: Text-to-Video Diffusion Models with An Expert Transformer](https://mlsanity.com/paper/2408.06072/) (2024)
- [SlowFast Networks for Video Recognition](https://mlsanity.com/paper/1812.03982/) (2018)
- [VBench: Comprehensive Benchmark Suite for Video Generative Models](https://mlsanity.com/paper/2311.17982/) (2023)
- [Towards Accurate Generative Models of Video: A New Metric & Challenges](https://mlsanity.com/paper/1812.01717/) (2018)
- [A Comprehensive Survey on Transfer Learning](https://mlsanity.com/paper/1911.02685/) (2019)
- [MViTv2: Improved Multiscale Vision Transformers for Classification and Detection](https://mlsanity.com/paper/2112.01526/) (2021)
- [Video Generation From Text](https://mlsanity.com/paper/1710.00421/) (2017)
- [MiraData: A Large-Scale Video Dataset with Long Durations and Structured Captions](https://mlsanity.com/paper/2407.06358/) (2024)
- [Endora: Video Generation Models as Endoscopy Simulators](https://mlsanity.com/paper/2403.11050/) (2024)
- [HecVL: Hierarchical Video-Language Pretraining for Zero-shot Surgical Phase Recognition](https://mlsanity.com/paper/2405.10075/) (2024)
- [OphNet: A Large-Scale Video Benchmark for Ophthalmic Surgical Workflow Understanding](https://mlsanity.com/paper/2406.07471/) (2024)
- [OphCLIP: Hierarchical Retrieval-Augmented Learning for Ophthalmic Surgical Video-Language Pretraining](https://mlsanity.com/paper/2411.15421/) (2024)
- [SurGen: Text-Guided Diffusion Model for Surgical Video Generation](https://mlsanity.com/paper/2408.14028/) (2024)
- [Bora: Biomedical Generalist Video Generation Model](https://mlsanity.com/paper/2407.08944/) (2024)
- [Interactive Generation of Laparoscopic Videos with Diffusion Models](https://mlsanity.com/paper/2406.06537/) (2024)
- [Why Deep Surgical Models Fail?: Revisiting Surgical Action Triplet Recognition through the Lens of Robustness](https://mlsanity.com/paper/2209.08647/) (2022)

## Built on by (most cited first, 10 of 10)

- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [UniMedVL: Unifying Medical Multimodal Understanding and Generation through Observation-Knowledge-Analysis](https://mlsanity.com/paper/2510.15710/) (2025)
- [SciReasoner: Laying the Scientific Reasoning Ground Across Disciplines](https://mlsanity.com/paper/2509.21320/) (2025)
- [RetinaLogos: Fine-Grained Synthesis of High-Resolution Retinal Images Through Captions](https://mlsanity.com/paper/2505.12887/) (2025)
- [From Articulated Kinematics to Routed Visual Control for Action-Conditioned Surgical Video Generation](https://mlsanity.com/paper/2605.08712/) (2026)
- [Project Imaging-X: A Survey of 1000+ Open-Access Medical Imaging Datasets for Foundation Model Development](https://mlsanity.com/paper/2603.27460/) (2026)
- [OphEdit: Training-Free Text-Guided Editing of Ophthalmic Surgical Videos](https://mlsanity.com/paper/2605.07695/) (2026)
- [Surg-UniWorld: A Unified Surgical World Model with Multimodal Control Experts](https://mlsanity.com/paper/2608.06770/) (2026)
- [Surgical Video Generation From Diffusion to World Models: A Survey](https://mlsanity.com/paper/2608.26214/) (2026)
- [Hierarchical Curriculum Learning for Surgical Video Generation: Focusing on Bilateral Axillo-Breast Approach Robotic Thyroidectomy Datasets](https://mlsanity.com/paper/2610.17684/) (2026)

## Abstract (arXiv)

In ophthalmic surgery, developing an AI system capable of interpreting surgical videos and predicting subsequent operations requires numerous ophthalmic surgical videos with high-quality annotations, which are difficult to collect due to privacy concerns and labor consumption. Text-guided video generation (T2V) emerges as a promising solution to overcome this issue by generating ophthalmic surgical videos based on surgeon instructions. In this paper, we present Ophora, a pioneering model that can generate ophthalmic surgical videos following natural language instructions. To construct Ophora, we first propose a Comprehensive Data Curation pipeline to convert narrative ophthalmic surgical videos into a large-scale, high-quality dataset comprising over 160K video-instruction pairs, Ophora-160K. Then, we propose a Progressive Video-Instruction Tuning scheme to transfer rich spatial-temporal knowledge from a T2V model pre-trained on natural video-text datasets for privacy-preserved ophthalmic surgical video generation based on Ophora-160K. Experiments on video quality evaluation via quantitative analysis and ophthalmologist feedback demonstrate that Ophora can generate realistic and reliable ophthalmic surgical videos based on surgeon instructions. We also validate the capability of Ophora for empowering downstream tasks of ophthalmic surgical workflow understanding. Code is available at https://github.com/uni-medical/Ophora.