# Aligning Large Language Models with Healthcare Stakeholders: A Pathway to Trustworthy AI Integration

arXiv: https://arxiv.org/abs/2505.02848 · HTML: https://mlsanity.com/paper/2505.02848/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical LLM alignment, one of 10 directions in LLM alignment / RLHF / preference optimisation.
- Builds on 43 of its 75 references that are in the map.
- First posted on arXiv 2 May 2025.

## Placed in

- LLM alignment / RLHF / preference optimisation / [Medical LLM alignment](https://mlsanity.com/alignment/medical-llm-alignment/)

## Builds on (most cited first, 30 of 43)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Survey of Hallucination in Natural Language Generation](https://mlsanity.com/paper/2202.03629/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [The RefinedWeb Dataset for Falcon LLM: Outperforming Curated Corpora with Web Data, and Web Data Only](https://mlsanity.com/paper/2306.01116/) (2023)
- [Galactica: A Large Language Model for Science](https://mlsanity.com/paper/2211.09085/) (2022)
- [DetectGPT: Zero-Shot Machine-Generated Text Detection using Probability Curvature](https://mlsanity.com/paper/2301.11305/) (2023)
- [RLAIF vs. RLHF: Scaling Reinforcement Learning from Human Feedback with AI Feedback](https://mlsanity.com/paper/2309.00267/) (2023)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [RRHF: Rank Responses to Align Language Models with Human Feedback without tears](https://mlsanity.com/paper/2304.05302/) (2023)
- [Fine-Grained Human Feedback Gives Better Rewards for Language Model Training](https://mlsanity.com/paper/2306.01693/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [Large Language Model Alignment: A Survey](https://mlsanity.com/paper/2309.15025/) (2023)
- [GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Records](https://mlsanity.com/paper/2203.03540/) (2022)
- [Can large language models reason about medical questions?](https://mlsanity.com/paper/2207.08143/) (2022)
- [A Study of Generative Large Language Model for Medical Research and Healthcare](https://mlsanity.com/paper/2305.13523/) (2023)
- [MentalBERT: Publicly Available Pretrained Language Models for Mental Healthcare](https://mlsanity.com/paper/2110.15621/) (2021)
- [Continual Learning for Large Language Models: A Survey](https://mlsanity.com/paper/2402.01364/) (2024)
- [On the Challenges and Perspectives of Foundation Models for Medical Image Analysis](https://mlsanity.com/paper/2306.05705/) (2023)
- [ProGen: Language Modeling for Protein Generation](https://mlsanity.com/paper/2004.03497/) (2020)
- [Diagnostic Reasoning Prompts Reveal the Potential for Large Language Model Interpretability in Medicine](https://mlsanity.com/paper/2308.06834/) (2023)
- [Matching Patients to Clinical Trials with Large Language Models](https://mlsanity.com/paper/2307.15051/) (2023)

## Built on by (most cited first, 1 of 1)

- [Can "AI" Be a Doctor? A Study of Empathy, Readability, and Alignment in Clinical LLMs](https://mlsanity.com/paper/2604.20791/) (2026)

## Abstract (arXiv)

The wide exploration of large language models (LLMs) raises the awareness of alignment between healthcare stakeholder preferences and model outputs. This alignment becomes a crucial foundation to empower the healthcare workflow effectively, safely, and responsibly. Yet the varying behaviors of LLMs may not always match with healthcare stakeholders' knowledge, demands, and values. To enable a human-AI alignment, healthcare stakeholders will need to perform essential roles in guiding and enhancing the performance of LLMs. Human professionals must participate in the entire life cycle of adopting LLM in healthcare, including training data curation, model training, and inference. In this review, we discuss the approaches, tools, and applications of alignments between healthcare stakeholders and LLMs. We demonstrate that LLMs can better follow human values by properly enhancing healthcare knowledge integration, task understanding, and human guidance. We provide outlooks on enhancing the alignment between humans and LLMs to build trustworthy real-world healthcare applications.