# Eterna is Solved

arXiv: https://arxiv.org/abs/2505.02110 · HTML: https://mlsanity.com/paper/2505.02110/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 21 references that are in the map.
- First posted on arXiv 4 May 2025.

## Builds on (most cited first, 5 of 5)

- [Designing RNA Secondary Structures is Hard](https://mlsanity.com/paper/1710.11513/) (2017)
- [Generalized Nested Rollout Policy Adaptation](https://mlsanity.com/paper/2003.10024/) (2020)
- [Monte Carlo Inverse Folding](https://mlsanity.com/paper/2005.09961/) (2020)
- [Learning a Prior for Monte Carlo Search by Replaying Solutions to Combinatorial Problems](https://mlsanity.com/paper/2401.10431/) (2024)
- [Stabilized Nested Rollout Policy Adaptation](https://mlsanity.com/paper/2101.03563/) (2021)

## Abstract (arXiv)

RNA design consists of discovering a nucleotide sequence that folds into a target secondary structure. It is useful for synthetic biology, medicine, and nanotechnology. We propose Montparnasse, a Multi Objective Generalized Nested Rollout Policy Adaptation with Limited Repetition (MOGNRPALR) RNA design algorithm. It solves the Eterna benchmark.