# Mamba Based Feature Extraction And Adaptive Multilevel Feature Fusion For 3D Tumor Segmentation From Multi-modal Medical Image

arXiv: https://arxiv.org/abs/2504.21281 · HTML: https://mlsanity.com/paper/2504.21281/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 12 of its 20 references that are in the map.
- First posted on arXiv 30 Apr 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 12 of 12)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [Combining Recurrent, Convolutional, and Continuous-time Models with Linear State-Space Layers](https://mlsanity.com/paper/2110.13985/) (2021)
- [3D MRI brain tumor segmentation using autoencoder regularization](https://mlsanity.com/paper/1810.11654/) (2018)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [MedNeXt: Transformer-driven Scaling of ConvNets for Medical Image Segmentation](https://mlsanity.com/paper/2303.09975/) (2023)
- [3D UX-Net: A Large Kernel Volumetric ConvNet Modernizing Hierarchical Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2209.15076/) (2022)
- [MambaHSI: Spatial-Spectral Mamba for Hyperspectral Image Classification](https://mlsanity.com/paper/2501.04944/) (2025)
- [Deform-Mamba Network for MRI Super-Resolution](https://mlsanity.com/paper/2407.05969/) (2024)
- [Application of belief functions to medical image segmentation: A review](https://mlsanity.com/paper/2205.01733/) (2022)

## Built on by (most cited first, 1 of 1)

- [PAS-Mamba: Phase-Amplitude-Spatial State Space Model for MRI Reconstruction](https://mlsanity.com/paper/2601.14530/) (2026)

## Abstract (arXiv)

Multi-modal 3D medical image segmentation aims to accurately identify tumor regions across different modalities, facing challenges from variations in image intensity and tumor morphology. Traditional convolutional neural network (CNN)-based methods struggle with capturing global features, while Transformers-based methods, despite effectively capturing global context, encounter high computational costs in 3D medical image segmentation. The Mamba model combines linear scalability with long-distance modeling, making it a promising approach for visual representation learning. However, Mamba-based 3D multi-modal segmentation still struggles to leverage modality-specific features and fuse complementary information effectively. In this paper, we propose a Mamba based feature extraction and adaptive multilevel feature fusion for 3D tumor segmentation using multi-modal medical image. We first develop the specific modality Mamba encoder to efficiently extract long-range relevant features that represent anatomical and pathological structures present in each modality. Moreover, we design an bi-level synergistic integration block that dynamically merges multi-modal and multi-level complementary features by the modality attention and channel attention learning. Lastly, the decoder combines deep semantic information with fine-grained details to generate the tumor segmentation map. Experimental results on medical image datasets (PET/CT and MRI multi-sequence) show that our approach achieve competitive performance compared to the state-of-the-art CNN, Transformer, and Mamba-based approaches.