# Talk Before You Retrieve: Agent-Led Discussions for Better RAG in Medical QA

arXiv: https://arxiv.org/abs/2504.21252 · HTML: https://mlsanity.com/paper/2504.21252/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 10 of its 18 references that are in the map.
- First posted on arXiv 30 Apr 2025.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)
- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 10 of 10)

- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [REALM: Retrieval-Augmented Language Model Pre-Training](https://mlsanity.com/paper/2002.08909/) (2020)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Leveraging Passage Retrieval with Generative Models for Open Domain Question Answering](https://mlsanity.com/paper/2007.01282/) (2020)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [Benchmarking Retrieval-Augmented Generation for Medicine](https://mlsanity.com/paper/2402.13178/) (2024)
- [MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrieval](https://mlsanity.com/paper/2307.00589/) (2023)
- [Seven Failure Points When Engineering a Retrieval Augmented Generation System](https://mlsanity.com/paper/2401.05856/) (2024)

## Built on by (most cited first, 6 of 6)

- [EZBlender: Efficient 3D Editing with Plan-and-ReAct Agent](https://mlsanity.com/paper/2601.07143/) (2026)
- [Empowering Real-World: A Survey on the Technology, Practice, and Evaluation of LLM-driven Industry Agents](https://mlsanity.com/paper/2510.17491/) (2025)
- [Contradictions in Context: Challenges for Retrieval-Augmented Generation in Healthcare](https://mlsanity.com/paper/2511.06668/) (2025)
- [OphIn-500K: Curating Web-Scale Visual Instructions for Scaling Ophthalmic Multimodal Large Language Models](https://mlsanity.com/paper/2605.27916/) (2026)
- [Self-MedRAG: a Self-Reflective Hybrid Retrieval-Augmented Generation Framework for Reliable Medical Question Answering](https://mlsanity.com/paper/2601.04531/) (2026)
- [When Cases Get Rare: A Retrieval Benchmark for Off-Guideline Clinical Question Answering](https://mlsanity.com/paper/2605.21807/) (2026)

## Abstract (arXiv)

Medical question answering (QA) is a reasoning-intensive task that remains challenging for large language models (LLMs) due to hallucinations and outdated domain knowledge. Retrieval-Augmented Generation (RAG) provides a promising post-training solution by leveraging external knowledge. However, existing medical RAG systems suffer from two key limitations: (1) a lack of modeling for human-like reasoning behaviors during information retrieval, and (2) reliance on suboptimal medical corpora, which often results in the retrieval of irrelevant or noisy snippets. To overcome these challenges, we propose Discuss-RAG, a plug-and-play module designed to enhance the medical QA RAG system through collaborative agent-based reasoning. Our method introduces a summarizer agent that orchestrates a team of medical experts to emulate multi-turn brainstorming, thereby improving the relevance of retrieved content. Additionally, a decision-making agent evaluates the retrieved snippets before their final integration. Experimental results on four benchmark medical QA datasets show that Discuss-RAG consistently outperforms MedRAG, especially significantly improving answer accuracy by up to 16.67% on BioASQ and 12.20% on PubMedQA. The code is available at: https://github.com/LLM-VLM-GSL/Discuss-RAG.