# Multimodal Large Language Models for Medicine: A Comprehensive Survey

arXiv: https://arxiv.org/abs/2504.21051 · HTML: https://mlsanity.com/paper/2504.21051/

## Key facts

- Cited by 16 papers in the map (data through 14 Oct 2026).
- Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 185 of its 300 references that are in the map.
- First posted on arXiv 29 Apr 2025.

## Placed in

- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)

## Builds on (most cited first, 30 of 185)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [BLIP: Bootstrapping Language-Image Pre-training for Unified Vision-Language Understanding and Generation](https://mlsanity.com/paper/2201.12086/) (2022)
- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Qwen Technical Report](https://mlsanity.com/paper/2309.16609/) (2023)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Tasks](https://mlsanity.com/paper/2312.14238/) (2023)
- [The Pile: An 800GB Dataset of Diverse Text for Language Modeling](https://mlsanity.com/paper/2101.00027/) (2020)
- [BEiT: BERT Pre-Training of Image Transformers](https://mlsanity.com/paper/2106.08254/) (2021)
- [HuBERT: Self-Supervised Speech Representation Learning by Masked Prediction of Hidden Units](https://mlsanity.com/paper/2106.07447/) (2021)
- [ViLBERT: Pretraining Task-Agnostic Visiolinguistic Representations for Vision-and-Language Tasks](https://mlsanity.com/paper/1908.02265/) (2019)
- [Extracting Training Data from Large Language Models](https://mlsanity.com/paper/2012.07805/) (2020)

## Built on by (most cited first, 16 of 16)

- [A Survey of Multimodal Hallucination Evaluation and Detection](https://mlsanity.com/paper/2507.19024/) (2025)
- [OmniBrainBench: A Comprehensive Multimodal Benchmark for Brain Imaging Analysis Across Multi-stage Clinical Tasks](https://mlsanity.com/paper/2511.00846/) (2025)
- [MTMCS-Bench: Evaluating Contextual Safety of Multimodal Large Language Models in Multi-Turn Dialogues](https://mlsanity.com/paper/2601.06757/) (2026)
- [Unveiling and Bridging the Functional Perception Gap in MLLMs: Atomic Visual Alignment and Hierarchical Evaluation via PET-Bench](https://mlsanity.com/paper/2601.02737/) (2026)
- [Radiology's Last Exam (RadLE): Benchmarking Frontier Multimodal AI Against Human Experts and a Taxonomy of Visual Reasoning Errors in Radiology](https://mlsanity.com/paper/2509.25559/) (2025)
- [Human or LLM as Standardized Patients? A Comparative Study for Medical Education](https://mlsanity.com/paper/2511.14783/) (2025)
- [From Compound Figures to Composite Understanding: Developing a Multi-Modal LLM from Biomedical Literature with Medical Multiple-Image Benchmarking and Validation](https://mlsanity.com/paper/2511.22232/) (2025)
- [Med-Scout: Curing MLLMs' Geometric Blindness in Medical Perception via Geometry-Aware RL Post-Training](https://mlsanity.com/paper/2601.23220/) (2026)
- [The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomy](https://mlsanity.com/paper/2607.11175/) (2026)
- [SpiroLLM: Finetuning Pretrained LLMs to Understand Spirogram Time Series with Clinical Validation in COPD Reporting](https://mlsanity.com/paper/2507.16145/) (2025)
- [TomoGraphView: 3D Medical Image Classification with Omnidirectional Slice Representations and Graph Neural Networks](https://mlsanity.com/paper/2511.09605/) (2025)
- [BreastGPT: A Multimodal Large Language Model for the Full Spectrum of Breast Cancer Clinical Routine](https://mlsanity.com/paper/2606.04911/) (2026)
- [Generating Findings for Jaw Cysts in Dental Panoramic Radiographs Using a GPT-Based VLM: A Preliminary Study on Building a Two-Stage Self-Correction Loop with Structured Output (SLSO) Framework](https://mlsanity.com/paper/2510.02001/) (2025)
- [Towards Responsible Multimodal Medical Reasoning via Context-Aligned Vision-Language Models](https://mlsanity.com/paper/2604.08815/) (2026)
- [Learning from Medical Entity Trees: An Entity-Centric Medical Data Engineering Framework for MLLMs](https://mlsanity.com/paper/2604.25296/) (2026)
- [MULTISEISMO: A Multimodal Seismic Dataset and Model for Cross-Modal Seismic Understanding](https://mlsanity.com/paper/2605.26320/) (2026)

## Abstract (arXiv)

MLLMs have recently become a focal point in the field of artificial intelligence research. Building on the strong capabilities of LLMs, MLLMs are adept at addressing complex multi-modal tasks. With the release of GPT-4, MLLMs have gained substantial attention from different domains. Researchers have begun to explore the potential of MLLMs in the medical and healthcare domain. In this paper, we first introduce the background and fundamental concepts related to LLMs and MLLMs, while emphasizing the working principles of MLLMs. Subsequently, we summarize three main directions of application within healthcare: medical reporting, medical diagnosis, and medical treatment. Our findings are based on a comprehensive review of 330 recent papers in this area. We illustrate the remarkable capabilities of MLLMs in these domains by providing specific examples. For data, we present six mainstream modes of data along with their corresponding evaluation benchmarks. At the end of the survey, we discuss the challenges faced by MLLMs in the medical and healthcare domain and propose feasible methods to mitigate or overcome these issues.