# Low-Rank Adaptive Structural Priors for Generalizable Diabetic Retinopathy Grading

arXiv: https://arxiv.org/abs/2504.19362 · HTML: https://mlsanity.com/paper/2504.19362/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 29 of its 51 references that are in the map.
- First posted on arXiv 27 Apr 2025.

## Builds on (most cited first, 29 of 29)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Deep CORAL: Correlation Alignment for Deep Domain Adaptation](https://mlsanity.com/paper/1607.01719/) (2016)
- [Domain Generalization: A Survey](https://mlsanity.com/paper/2103.02503/) (2021)
- [Domain Generalization with MixStyle](https://mlsanity.com/paper/2104.02008/) (2021)
- [Gradient Matching for Domain Generalization](https://mlsanity.com/paper/2104.09937/) (2021)
- [Deep Domain-Adversarial Image Generation for Domain Generalisation](https://mlsanity.com/paper/2003.06054/) (2020)
- [Improving Out-of-Distribution Robustness via Selective Augmentation](https://mlsanity.com/paper/2201.00299/) (2022)
- [Fishr: Invariant Gradient Variances for Out-of-Distribution Generalization](https://mlsanity.com/paper/2109.02934/) (2021)
- [Domain Generalization for Medical Imaging Classification with Linear-Dependency Regularization](https://mlsanity.com/paper/2009.12829/) (2020)
- [Causality-inspired Single-source Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2111.12525/) (2021)
- [Dynamic Snake Convolution based on Topological Geometric Constraints for Tubular Structure Segmentation](https://mlsanity.com/paper/2307.08388/) (2023)
- [C-Mixup: Improving Generalization in Regression](https://mlsanity.com/paper/2210.05775/) (2022)
- [A Benchmark for Studying Diabetic Retinopathy: Segmentation, Grading, and Transferability](https://mlsanity.com/paper/2008.09772/) (2020)
- [CANet: Cross-disease Attention Network for Joint Diabetic Retinopathy and Diabetic Macular Edema Grading](https://mlsanity.com/paper/1911.01376/) (2019)
- [Learn to Segment Retinal Lesions and Beyond](https://mlsanity.com/paper/1912.11619/) (2019)
- [Zoom-in-Net: Deep Mining Lesions for Diabetic Retinopathy Detection](https://mlsanity.com/paper/1706.04372/) (2017)
- [On Multi-Domain Long-Tailed Recognition, Imbalanced Domain Generalization and Beyond](https://mlsanity.com/paper/2203.09513/) (2022)
- [Lesion-based Contrastive Learning for Diabetic Retinopathy Grading from Fundus Images](https://mlsanity.com/paper/2107.08274/) (2021)
- [Towards Generalizable Diabetic Retinopathy Grading in Unseen Domains](https://mlsanity.com/paper/2307.04378/) (2023)
- [Learning Robust Representation for Joint Grading of Ophthalmic Diseases via Adaptive Curriculum and Feature Disentanglement](https://mlsanity.com/paper/2207.04183/) (2022)
- [GREEN: a Graph REsidual rE-ranking Network for Grading Diabetic Retinopathy](https://mlsanity.com/paper/2007.09968/) (2020)
- [Generalizing to Unseen Domains in Diabetic Retinopathy with Disentangled Representations](https://mlsanity.com/paper/2406.06384/) (2024)
- [Generalizing Across Domains in Diabetic Retinopathy via Variational Autoencoders](https://mlsanity.com/paper/2309.11301/) (2023)
- [Multi-Domain Long-Tailed Learning by Augmenting Disentangled Representations](https://mlsanity.com/paper/2210.14358/) (2022)
- [Domain Game: Disentangle Anatomical Feature for Single Domain Generalized Segmentation](https://mlsanity.com/paper/2406.02125/) (2024)

## Abstract (arXiv)

Diabetic retinopathy (DR), a serious ocular complication of diabetes, is one of the primary causes of vision loss among retinal vascular diseases. Deep learning methods have been extensively applied in the grading of diabetic retinopathy (DR). However, their performance declines significantly when applied to data outside the training distribution due to domain shifts. Domain generalization (DG) has emerged as a solution to this challenge. However, most existing DG methods overlook lesion-specific features, resulting in insufficient accuracy. In this paper, we propose a novel approach that enhances existing DG methods by incorporating structural priors, inspired by the observation that DR grading is heavily dependent on vessel and lesion structures. We introduce Low-rank Adaptive Structural Priors (LoASP), a plug-and-play framework designed for seamless integration with existing DG models. LoASP improves generalization by learning adaptive structural representations that are finely tuned to the complexities of DR diagnosis. Extensive experiments on eight diverse datasets validate its effectiveness in both single-source and multi-source domain scenarios. Furthermore, visualizations reveal that the learned structural priors intuitively align with the intricate architecture of the vessels and lesions, providing compelling insights into their interpretability and diagnostic relevance.