# 3D Deep-learning-based Segmentation of Human Skin Sweat Glands and Their 3D Morphological Response to Temperature Variations

arXiv: https://arxiv.org/abs/2504.17255 · HTML: https://mlsanity.com/paper/2504.17255/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 25 of its 53 references that are in the map.
- First posted on arXiv 24 Apr 2025.

## Builds on (most cited first, 25 of 25)

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## Abstract (arXiv)

Skin, the primary regulator of heat exchange, relies on sweat glands for thermoregulation. Alterations in sweat gland morphology play a crucial role in various pathological conditions and clinical diagnoses. Current methods for observing sweat gland morphology are limited by their two-dimensional, in vitro, and destructive nature, underscoring the urgent need for real-time, non-invasive, quantifiable technologies. We proposed a novel three-dimensional (3D) transformer-based multi-object segmentation framework, integrating a sliding window approach, joint spatial-channel attention mechanism, and architectural heterogeneity between shallow and deep layers. Our proposed network enables precise 3D sweat gland segmentation from skin volume data captured by optical coherence tomography (OCT). For the first time, subtle variations of sweat gland 3D morphology in response to temperature changes, have been visualized and quantified. Our approach establishes a benchmark for normal sweat gland morphology and provides a real-time, non-invasive tool for quantifying 3D structural parameters. This enables the study of individual variability and pathological changes in sweat gland structure, advancing dermatological research and clinical applications, including thermoregulation and bromhidrosis treatment.