# Deep Generative Model-Based Generation of Synthetic Individual-Specific Brain MRI Segmentations

arXiv: https://arxiv.org/abs/2504.12352 · HTML: https://mlsanity.com/paper/2504.12352/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 57 references that are in the map.
- First posted on arXiv 15 Apr 2025.

## Builds on (most cited first, 22 of 22)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
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- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [FaceNet: A Unified Embedding for Face Recognition and Clustering](https://mlsanity.com/paper/1503.03832/) (2015)
- [Improved Training of Wasserstein GANs](https://mlsanity.com/paper/1704.00028/) (2017)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [MONAI: An open-source framework for deep learning in healthcare](https://mlsanity.com/paper/2211.02701/) (2022)
- [Med3D: Transfer Learning for 3D Medical Image Analysis](https://mlsanity.com/paper/1904.00625/) (2019)
- [Brain Imaging Generation with Latent Diffusion Models](https://mlsanity.com/paper/2209.07162/) (2022)
- [Deep Generative Modelling: A Comparative Review of VAEs, GANs, Normalizing Flows, Energy-Based and Autoregressive Models](https://mlsanity.com/paper/2103.04922/) (2021)
- [A Survey on Generative Adversarial Networks: Variants, Applications, and Training](https://mlsanity.com/paper/2006.05132/) (2020)
- [Conditional Diffusion Models for Semantic 3D Brain MRI Synthesis](https://mlsanity.com/paper/2305.18453/) (2023)
- [Generation of 3D Brain MRI Using Auto-Encoding Generative Adversarial Networks](https://mlsanity.com/paper/1908.02498/) (2019)
- [Hierarchical Amortized Training for Memory-efficient High Resolution 3D GAN](https://mlsanity.com/paper/2008.01910/) (2020)
- [Variational Approaches for Auto-Encoding Generative Adversarial Networks](https://mlsanity.com/paper/1706.04987/) (2017)
- [Inflating 2D Convolution Weights for Efficient Generation of 3D Medical Images](https://mlsanity.com/paper/2208.03934/) (2022)

## Abstract (arXiv)

To the best of our knowledge, all existing methods that can generate synthetic brain magnetic resonance imaging (MRI) scans for a specific individual require detailed structural or volumetric information about the individual's brain. However, such brain information is often scarce, expensive, and difficult to obtain. In this paper, we propose the first approach capable of generating synthetic brain MRI segmentations -- specifically, 3D white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) segmentations -- for individuals using their easily obtainable and often readily available demographic, interview, and cognitive test information. Our approach features a novel deep generative model, CSegSynth, which outperforms existing prominent generative models, including conditional variational autoencoder (C-VAE), conditional generative adversarial network (C-GAN), and conditional latent diffusion model (C-LDM). We demonstrate the high quality of our synthetic segmentations through extensive evaluations. Also, in assessing the effectiveness of the individual-specific generation, we achieve superior volume prediction, with mean absolute errors of only 36.44mL, 29.20mL, and 35.51mL between the ground-truth WM, GM, and CSF volumes of test individuals and those volumes predicted based on generated individual-specific segmentations, respectively.